8ESV
Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008593 | biological_process | regulation of Notch signaling pathway |
| B | 0009986 | cellular_component | cell surface |
| B | 0016020 | cellular_component | membrane |
| B | 0016604 | cellular_component | nuclear body |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0030054 | cellular_component | cell junction |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| B | 0051043 | biological_process | regulation of membrane protein ectodomain proteolysis |
| B | 0051604 | biological_process | protein maturation |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0097197 | cellular_component | tetraspanin-enriched microdomain |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TFAHEVGHNF |
| Chain | Residue | Details |
| A | THR380-PHE389 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR215-HIS221 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 236 |
| Details | Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 94 |
| Details | Domain: {"description":"Disintegrin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00068","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29430990","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24055016","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37516108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ESV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37516108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ESV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29224781","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6BE6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 137 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 9 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34739841","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
