Author results

5WYI
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THE YAF9 YEATS DOMAIN RECOGNIZING H3K122SUC PEPTIDE
分子名称:Yaf9, ILE-MET-PRO-LYS-ASP-ILE-GLN-LEU, (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, ...
著者Wang, Y., Hao, Q.
登録日2017-01-13
公開日2018-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Yaf9 YEATS domain Recognizing H3K122suc Peptide
To Be Published
5Y8V
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CRYSTAL STRUCTURE OF GAS41
分子名称:YEATS domain-containing protein 4, MAGNESIUM ION
著者Wang, Y., Hao, Q.
登録日2017-08-21
公開日2018-04-25
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLQ
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8E9E
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
著者Wang, Y., Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLR
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8E9E6SS
分子名称:IAg7 alpha chain, H2-Ab1 protein, 1,2-ETHANEDIOL
著者Wang, Y., Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLX
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CRYSTAL STRUCTURE OF IAG7 IN COMPLEX WITH INSULIN MIMOTOPE P8G9E
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
著者Wang, Y., Dai, S.
登録日2017-11-11
公開日2017-12-20
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (2.323 Å)
主引用文献C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DFQ
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MOUSE DIABETOGENIC TCR I.29
分子名称:TCR alpha chain, TCR beta chain, CALCIUM ION, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFS
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MOUSE TCR I.29 IN COMPLEX WITH IAG7-P8E9E6SS
分子名称:mouse TCR alpha chain, mouse TCR beta chain, H-2 class II histocompatibility antigen, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFV
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MOUSE DIABETOGENIC TCR 8F10
分子名称:TCR alpha chain, TCR beta chain, 1,2-ETHANEDIOL
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFW
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TCR 8F10 IN COMPLEX WITH IAG7-P8G9E
分子名称:H-2 class II histocompatibility antigen, A-D alpha chain, H2-Ab1 protein, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6DFX
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HUMAN DIABETOGENIC TCR T1D3 IN COMPLEX WITH DQ8-P8E9E PEPTIDE
分子名称:MHC class II HLA-DQ-alpha chain, MHC class II antigen, T1D3 alpha chain, ...
著者Wang, Y., Dai, S.
登録日2018-05-15
公開日2019-04-17
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
Sci Immunol, 4, 2019
6AEJ
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CRYSTAL STRUCTURE OF HUMAN FTO IN COMPLEX WITH SMALL-MOLECULE INHIBITORS
分子名称:Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile, ZINC ION
著者Wang, Y., Cao, R., Peng, S., Zhang, W., Huang, N.
登録日2018-08-05
公開日2019-06-19
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
6AK4
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CRYSTAL STRUCTURE OF HUMAN FTO IN COMPLEX WITH SMALL-MOLECULE INHIBITORS
分子名称:Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide
著者Wang, Y., Cao, R., Peng, S., Zhang, W., Huang, N.
登録日2018-08-30
公開日2019-07-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
5YVE
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CRYSTAL STRUCTURE OF HUMAN P2X3 RECEPTOR IN COMPLEX WITH THE AF-219 NEGATIVE ALLOSTERIC MODULATOR
分子名称:P2X purinoceptor 3, MAGNESIUM ION, SODIUM ION, ...
著者Wang, Y., Hattori, M.
登録日2017-11-25
公開日2018-04-04
最終更新日2018-05-23
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Druggable negative allosteric site of P2X3 receptors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5H1K
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CRYSTAL STRUCTURE OF WD40 REPEAT DOMAINS OF GEMIN5 IN COMPLEX WITH 13-NT U4 SNRNA FRAGMENT
分子名称:Gem-associated protein 5, U4 snRNA (5'-R(*GP*CP*AP*AP*UP*UP*UP*UP*UP*GP*AP*CP*A)-3')
著者Wang, Y., Jin, W., Liu, C.P., Yang, N., Jin, M., Cong, Y., Wang, M., Xu, R.M.
登録日2016-10-10
公開日2016-11-23
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
139D
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SOLUTION STRUCTURE OF A PARALLEL-STRANDED G-QUADRUPLEX DNA
分子名称:DNA (5'-D(*TP*TP*GP*GP*GP*GP*T)-3')
著者Patel, D.J., Wang, Y.
登録日1993-09-28
公開日1994-01-31
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of a parallel-stranded G-quadruplex DNA.
J.Mol.Biol., 234, 1993
2R6W
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ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO A SERM
分子名称:Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone
著者Wang, Y.
登録日2007-09-06
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2R6Y
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ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A SERM
分子名称:Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl][4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
著者Wang, Y.
登録日2007-09-06
公開日2008-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3NYL
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THE X-RAY STRUCTURE OF AN ANTIPARALLEL DIMER OF THE HUMAN AMYLOID PRECURSOR PROTEIN E2 DOMAIN
分子名称:Amyloid beta (A4) protein (Peptidase nexin-II, Alzheimer disease), isoform CRA_b
著者Ha, Y., Hu, J., Lee, S., Liu, X., Wang, Y.
登録日2010-07-15
公開日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Mol.Cell, 15, 2004
5FNV
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A NEW COMPLEX STRUCTURE OF TUBULIN WITH AN ALPHA-BETA UNSATURATED LACTONE
分子名称:TUBULIN ALPHA-1B CHAIN, TUBULIN BETA CHAIN, STATHMIN-4, ...
著者Wang, Y., Naismith, J., Zhu, X.
登録日2015-11-16
公開日2016-05-18
最終更新日2016-07-13
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule.
Nat.Commun., 7, 2016
5XG8
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GALECTIN-13/PLACENTAL PROTEIN 13 VARIANT R53H CRYSTAL STRUCTURE
分子名称:Galactoside-binding soluble lectin 13, GLYCEROL
著者Wang, Y., Su, J.Y.
登録日2017-04-12
公開日2018-01-31
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138
Sci Rep, 8, 2018
5Y03
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GALECTIN-13/PLACENTAL PROTEIN 13 VARIANT R53H CRYSTAL STRUCTURE
分子名称:Galactoside-binding soluble lectin 13
著者Wang, Y., Su, J.
登録日2017-07-14
公開日2018-01-31
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Galectin-13, a different prototype galectin, does not bind beta-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138.
Sci Rep, 8, 2018
5Z2X
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STRUCTURE OF ALCOHOL DEHYDROGENASE FROM KLUYVEROMYCES POLYSPORA(KPADH)
分子名称:Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
著者Wang, Y., Zhou, J.Y., Hou, X.D., Xu, G.C., Wu, L., Rao, Y.J., ZHou, J.H., Ni, Y.
登録日2018-01-04
公開日2019-01-02
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
J. Am. Chem. Soc., 140, 2018
5ZEC
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CRYSTAL STRUCTURE OF KLUYVEROMYCES POLYSPORA ADH (KPADH) MUTANT (Q136N/F161V/S196G/E214G/S237C)
分子名称:Uncharacterized protein ADH, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ...
著者Wang, Y., ZHou, J.Y., Hou, X.D., Xu, G.C., Rao, Y.J., Wu, L., Zhou, J.H., Ni, Y.
登録日2018-02-27
公開日2019-01-02
実験手法X-RAY DIFFRACTION (1.779 Å)
主引用文献Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
J. Am. Chem. Soc., 140, 2018
5ZED
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CRYSTAL STRUCTURE OF KLUYVEROMYCES POLYSPORA ADH (KPADH) MUTANT (E214V/T215S)
分子名称:Uncharacterized protein ADH, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wang, Y., Zhou, J.Y., Hou, X.D., Xu, G.C., Wu, L., Rao, Y.J., ZHou, J.H., Ni, Y.
登録日2018-02-27
公開日2019-01-02
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
J. Am. Chem. Soc., 140, 2018
4J1R
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CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH INHIBITOR 15R
分子名称:Glycogen synthase kinase-3 beta, PHOSPHATE ION, (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, ...
著者Zhan, C., Wang, Y., Wach, J., Sheehan, P., Zhong, C., Harris, R., Patskovsky, Y., Bishop, J., Haggarty, S., Ramek, A., Berry, K., O'Herin, C., Koehler, A.N., Hung, A.W., Young, D.W., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC)
登録日2013-02-01
公開日2013-03-20
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor
To be Published