Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex

Summary for 4ZHQ

Related4ZI7 4ZOL 5BMV
Related PRD IDPRD_002173
DescriptorTubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ... (13 entities in total)
Functional Keywordsstructural protein-inhibitor complex, structural protein/inhibitor
Biological sourceRattus norvegicus (Rat)
Cellular locationCytoplasm, cytoskeleton Q2XVP4 P02554
Golgi apparatus  P63043
Total number of polymer chains6
Total molecular weight265947.72
Wang, Y.,Zhang, R. (deposition date: 2015-04-26, release date: 2016-07-27)
Primary citation
Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J.
Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules
Mol.Pharmacol., 89:233-242, 2016
PubMed: 26660762 (PDB entries with the same primary citation)
DOI: 10.1124/mol.115.100149
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24640.5%4.4%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution