Author results

6EBV
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH ADP AND PANTOTHENATE ANALOG DEOXY-N7-PAN
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, N-heptyl-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
Authors:Chen, Y., Antoshchenko, T., Strauss, E., Barnard, L., Huang, Y.H., Park, H.
Deposit date:2018-08-07
Release date:2019-08-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
6R80
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STRUCTURE OF AFF4 C-TERMINAL HOMOLOGY DOMAIN
Descriptor:AF4/FMR2 family member 4
Authors:Chen, Y., Cramer, P.
Deposit date:2019-03-30
Release date:2019-06-12
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization.
J.Biol.Chem., 294, 2019
4U5J
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C-SRC IN COMPLEX WITH RUXOLITINIB
Descriptor:Proto-oncogene tyrosine-protein kinase Src, (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
Authors:Chen, Y., Duan, Y., Chen, L.
Deposit date:2014-07-25
Release date:2014-09-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation
Plos One, 9, 2014
6J67
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CRYSTAL STRUCTURE OF THE COMPOUND 34 IN A COMPLEX WITH TRF2
Descriptor:Telomeric repeat-binding factor 2, 3FB-PHE-B8R-LEU-5XU-PRO
Authors:Chen, Y., Yang, Y., Lei, M.
Deposit date:2019-01-14
Release date:2019-02-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction.
ACS Med Chem Lett, 9, 2018
2NYM
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CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE 2A (PP2A) WITH C-TERMINUS TRUNCATED CATALYTIC SUBUNIT
Descriptor:Protein phosphatase 2, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Chen, Y., Xing, Y., Xu, Y., Chao, Y., Lin, Z., Jeffrey, P.D., Shi, Y.
Deposit date:2006-11-21
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
1C77
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STAPHYLOKINASE (SAK) DIMER
Descriptor:STAPHYLOKINASE
Authors:Rao, Z., Jiang, F., Liu, Y., Zhang, X., Chen, Y., Bartlam, M., Song, H., Ding, Y.
Deposit date:2000-02-01
Release date:2000-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a staphylokinase: variant a model for reduced antigenicity.
Eur.J.Biochem., 269, 2002
1C78
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STAPHYLOKINASE (SAK) DIMER
Descriptor:STAPHYLOKINASE
Authors:Rao, Z., Jiang, F., Liu, Y., Zhang, X., Chen, Y., Bartlam, M., Song, H., Ding, Y.
Deposit date:2000-02-01
Release date:2000-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a staphylokinase: variant a model for reduced antigenicity.
Eur.J.Biochem., 269, 2002
1C79
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STAPHYLOKINASE (SAK) DIMER
Descriptor:STAPHYLOKINASE
Authors:Rao, Z., Jiang, F., Liu, Y., Zhang, X., Chen, Y., Bartlam, M., Song, H., Ding, Y.
Deposit date:2000-02-01
Release date:2000-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a staphylokinase: variant a model for reduced antigenicity.
Eur.J.Biochem., 269, 2002
5YC2
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CRYSTAL STRUCTURE OF INNER MEMBRANE PROTEIN BQT4 IN COMPLEX WITH TELOMERIC PROTEIN RAP1
Descriptor:Ubiquitin-like protein SMT3,Bouquet formation protein 4, DNA-binding protein rap1
Authors:Chen, Y., Hu, C.
Deposit date:2017-09-06
Release date:2018-11-14
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.
Nucleic Acids Res., 47, 2019
5YCA
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CRYSTAL STRUCTURE OF INNER MEMBRANE PROTEIN BQT4 IN COMPLEX WITH LEM2
Descriptor:Ubiquitin-like protein SMT3,Bouquet formation protein 4, Lap-Emerin-Man domain protein 2
Authors:Chen, Y., Hu, C.
Deposit date:2017-09-07
Release date:2018-11-14
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.
Nucleic Acids Res., 47, 2019
6A6W
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CRYSTAL STRUCTURE OF FISSION YEAST INNER MEMBRANE PROTEIN BQT4 IN COMPLEX WITH SAD1
Descriptor:Bouquet formation protein 4, Spindle pole body-associated protein sad1
Authors:Chen, Y., Hu, C.
Deposit date:2018-06-29
Release date:2018-11-14
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast.
Nucleic Acids Res., 47, 2019
2L3N
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SOLUTION STRUCTURE OF RAP1-TAZ1 FUSION PROTEIN
Descriptor:DNA-binding protein rap1, Telomere length regulator taz1
Authors:Zhou, Z.R., Wang, F., Chen, Y., Lei, M., Hu, H.
Deposit date:2010-09-19
Release date:2011-01-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
Nat.Struct.Mol.Biol., 2011
2OTP
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CRYSTAL STRUCTURE OF IMMUNOGLOBULIN-LIKE TRANSCRIPT 1 (ILT1/LIR7/LILRA2)
Descriptor:Leukocyte immunoglobulin-like receptor subfamily A member 2
Authors:Gao, F., Peng, H., Chen, Y., Liu, Y., Gao, G.F.
Deposit date:2007-02-08
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of 3D Domain Swapped Dimer of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2), Molecular Insight into Group 1 Activating Receptor Forming Unique MW Interaction Pattern
To be Published
3R24
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CRYSTAL STRUCTURE OF NSP10/NSP16 COMPLEX OF SARS CORONAVIRUS" IF POSSIBLE
Descriptor:2'-O-methyl transferase, Non-structural protein 10 and Non-structural protein 11, S-ADENOSYLMETHIONINE, ...
Authors:Liu, X., Guo, D., Su, C., Chen, Y.
Deposit date:2011-03-13
Release date:2011-10-26
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex.
Plos Pathog., 7, 2011
5Y18
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CRYSTAL STRUCTURE OF DAXX HELICAL BUNDLE DOMAIN IN COMPLEX WITH ATRX
Descriptor:Death domain-associated protein 6, Transcriptional regulator ATRX
Authors:Chen, Y., Wang, X.
Deposit date:2017-07-19
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Structural basis for DAXX interaction with ATRX
Protein Cell, 8, 2017
5ZUQ
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P DOMAIN OF GII.17-1978
Descriptor:VP1
Authors:Chen, Y., Li, X.
Deposit date:2018-05-08
Release date:2018-10-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.
J. Virol., 93, 2019
5ZUS
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P DOMAIN OF GII.17-2014/15
Descriptor:VP1
Authors:Chen, Y., Li, X.
Deposit date:2018-05-08
Release date:2018-10-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.
J. Virol., 93, 2019
5ZV5
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P DOMAIN OF GII.17-2014/15 COMPLEXED WITH A-TRISACCHARIDE
Descriptor:VP1, ALPHA-L-FUCOSE, ALPHA D-GALACTOSE, ...
Authors:Chen, Y., Li, X.
Deposit date:2018-05-09
Release date:2018-10-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.
J. Virol., 93, 2019
5ZV7
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P DOMAIN OF GII.17-2014/15 COMPLEXED WITH B-TRISACCHARIDE
Descriptor:VP1, ALPHA-L-FUCOSE, ALPHA D-GALACTOSE
Authors:Chen, Y., Li, X.
Deposit date:2018-05-09
Release date:2018-10-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.
J. Virol., 93, 2019
5ZV9
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P DOMAIN OF GII.13 NOROVIRUS CAPSID
Descriptor:Major capsid protein VP1, GLYCEROL
Authors:Chen, Y., Li, X.
Deposit date:2018-05-09
Release date:2018-10-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.
J. Virol., 93, 2019
5ZVC
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P DOMAIN OF GII.13 NOROVIRUS CAPSID COMPLEXED WITH LEWIS A TRISACCHARIDE
Descriptor:Major capsid protein VP1, GLYCEROL, ALPHA-L-FUCOSE, ...
Authors:Chen, Y., Li, X.
Deposit date:2018-05-10
Release date:2018-10-03
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.
J. Virol., 93, 2019
2IKQ
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CRYSTAL STRUCTURE OF MOUSE STS-1 PGM DOMAIN IN COMPLEX WITH PHOSPHATE
Descriptor:Suppressor of T-cell receptor signaling 1, PHOSPHATE ION
Authors:Chen, Y., Nassar, N.
Deposit date:2006-10-02
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR Signaling
Mol.Cell, 27, 2007
2LS0
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SOLUTION STRUCTURE OF THE TARGET RECOGNITION DOMAIN OF ZOOCIN A
Descriptor:Zoocin A endopeptidase
Authors:Timkovich, R., Chen, Y., Simmonds, R.S.
Deposit date:2012-04-17
Release date:2012-12-05
Last modified:2013-03-27
Method:SOLUTION NMR
Cite:Solution structure of the recombinant target recognition domain of zoocin A.
Proteins, 81, 2013
2N7X
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SOLUTION STRUCTURE OF MICRORNA 20B PRE-ELEMENT
Descriptor:RNA (5'-R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP*C)-3')
Authors:Yang, F., Chen, Y., Varani, G.
Deposit date:2015-09-25
Release date:2016-04-13
Last modified:2016-06-01
Method:SOLUTION NMR
Cite:Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.
Nucleic Acids Res., 44, 2016
2N82
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SOLUTION STRUCTURE OF THE COMPLEX OF MICRORNA 20B PRE-ELEMENT WITH RBFOX RRM
Descriptor:RNA (5'-R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP*C)-3'), RNA binding protein fox-1 homolog 1
Authors:Yang, F., Chen, Y., Varani, G.
Deposit date:2015-09-30
Release date:2016-04-13
Last modified:2016-06-01
Method:SOLUTION NMR
Cite:Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.
Nucleic Acids Res., 44, 2016