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1FS2
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BU of 1fs2 by Molmil
INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
Descriptor: SKP1, SKP2
Authors:Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R.E, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
Deposit date:2000-09-08
Release date:2000-11-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
1FS1
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BU of 1fs1 by Molmil
INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX
Descriptor: CYCLIN A/CDK2-ASSOCIATED P19, CYCLIN A/CDK2-ASSOCIATED P45
Authors:Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R.E, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
Deposit date:2000-09-08
Release date:2000-11-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
1FQV
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BU of 1fqv by Molmil
Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
Descriptor: SKP1, SKP2
Authors:Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
Deposit date:2000-09-06
Release date:2000-11-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
8QYO
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BU of 8qyo by Molmil
Human proteasome 20S core particle
Descriptor: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
8QYM
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BU of 8qym by Molmil
Human 20S proteasome assembly intermediate structure 3
Descriptor: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
8QZ9
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BU of 8qz9 by Molmil
Human 20S proteasome assembly intermediate structure 4
Descriptor: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
8QYS
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BU of 8qys by Molmil
Human preholo proteasome 20S core particle
Descriptor: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
8QYL
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BU of 8qyl by Molmil
Human 20S proteasome assembly intermediate structure 2
Descriptor: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
8QYN
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BU of 8qyn by Molmil
Human 20S proteasome assembly intermediate structure 5
Descriptor: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome maturation protein, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
8QYJ
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BU of 8qyj by Molmil
Human 20S proteasome assembly structure 1
Descriptor: Proteasome assembly chaperone 1, Proteasome assembly chaperone 2, Proteasome assembly chaperone 3, ...
Authors:Schulman, B.A, Hanna, J.W, Harper, J.W, Adolf, F, Du, J, Rawson, S.D, Walsh Jr, R.M, Goodall, E.A.
Deposit date:2023-10-26
Release date:2024-02-21
Last modified:2024-08-28
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Nat.Struct.Mol.Biol., 31, 2024
3IVQ
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BU of 3ivq by Molmil
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-CiSBC2
Descriptor: CiSBC2, Speckle-type POZ protein
Authors:Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3IVV
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BU of 3ivv by Molmil
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-PucSBC1_pep1
Descriptor: PucSBC1, Speckle-type POZ protein
Authors:Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S.
Deposit date:2009-09-01
Release date:2009-10-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases.
Mol.Cell, 36, 2009
3IVB
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BU of 3ivb by Molmil
Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin Ligases: SPOPMATH-MacroH2ASBCpep1
Descriptor: CHLORIDE ION, Core histone macro-H2A.1, Speckle-type POZ protein, ...
Authors:Schulman, B.A, Miller, D.J, Calabrese, M.F, Seyedin, S.
Deposit date:2009-08-31
Release date:2009-10-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure 9
To be Published
3RTR
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BU of 3rtr by Molmil
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
Descriptor: Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
Authors:Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A.
Deposit date:2011-05-03
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
7NSC
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BU of 7nsc by Molmil
Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase
Descriptor: Glucose-induced degradation protein 4 homolog, Glucose-induced degradation protein 8 homolog, Isoform 2 of Armadillo repeat-containing protein 8, ...
Authors:Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A.
Deposit date:2021-03-05
Release date:2021-05-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Mol.Cell, 81, 2021
7NS4
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BU of 7ns4 by Molmil
Catalytic module of yeast Chelator-GID SR4 E3 ubiquitin ligase
Descriptor: E3 ubiquitin-protein ligase RMD5, Protein FYV10, ZINC ION
Authors:Sherpa, D, Chrustowicz, J, Prabu, J.R, Schulman, B.A.
Deposit date:2021-03-05
Release date:2021-05-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Mol.Cell, 81, 2021
7WUG
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BU of 7wug by Molmil
GID subcomplex: Gid12 bound Substrate Receptor Scaffolding module
Descriptor: Glucose-induced degradation protein 8, HLJ1_G0042170.mRNA.1.CDS.1, Vacuolar import and degradation protein 24, ...
Authors:Qiao, S, Cheng, J.D, Schulman, B.A.
Deposit date:2022-02-08
Release date:2022-06-08
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation.
Nat Commun, 13, 2022
8CDK
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BU of 8cdk by Molmil
CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Schulman, B.A.
Deposit date:2023-01-31
Release date:2023-04-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
8CDJ
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BU of 8cdj by Molmil
CAND1 b-hairpin++-SCF-SKP2 CAND1 rolling SCF engaged
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Schulman, B.A.
Deposit date:2023-01-31
Release date:2023-04-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
7Z8B
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BU of 7z8b by Molmil
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Descriptor: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ...
Authors:Hopf, L.V.M, Schulman, B.A.
Deposit date:2022-03-17
Release date:2022-08-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
Nat.Struct.Mol.Biol., 29, 2022
2AST
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BU of 2ast by Molmil
Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
Descriptor: BENZAMIDINE, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ...
Authors:Hao, B, Zhang, N, Schulman, B.A, Wu, G, Pagano, M, Pavletich, N.P.
Deposit date:2005-08-24
Release date:2005-10-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
8RHZ
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BU of 8rhz by Molmil
Structure of CUL9-RBX1 ubiquitin E3 ligase complex in unneddylated conformation - symmetry expanded unneddylated dimer
Descriptor: Cullin-9, E3 ubiquitin-protein ligase RBX1, ZINC ION
Authors:Hopf, L.V.M, Horn-Ghetko, D, Prabu, J.R, Schulman, B.A.
Deposit date:2023-12-17
Release date:2024-04-17
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.
Nat.Struct.Mol.Biol., 31, 2024
6P5W
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BU of 6p5w by Molmil
Structure of DCN1 bound to 3-methyl-N-((4S,5S)-3-methyl-6-oxo-1-phenyl-4-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide
Descriptor: 3-methyl-N-[(4S,5S)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide, Lysozyme,DCN1-like protein 1 chimera
Authors:Guy, R.K, Kim, H.S, Hammill, J.T, Scott, D.C, Schulman, B.A.
Deposit date:2019-05-31
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
J.Med.Chem., 62, 2019
7OD1
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BU of 7od1 by Molmil
Crystal structure of RBR ubiquitin ligase ARIH2
Descriptor: E3 ubiquitin-protein ligase ARIH2, ZINC ION
Authors:Kostrhon, S.P, Prabu, J.R, Schulman, B.A.
Deposit date:2021-04-28
Release date:2021-09-15
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
Nat.Chem.Biol., 17, 2021
6P5V
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BU of 6p5v by Molmil
Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-methylbenzamide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Lysozyme,DCN1-like protein 1 fusion, N-[(4S,5S)-1-[(1S)-cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide
Authors:Guy, R.K, Kim, H.S, Hammill, J.T, Scott, D.C, Schulman, B.A.
Deposit date:2019-05-31
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
J.Med.Chem., 62, 2019

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