1FS1

INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX

Summary for 1FS1

Entry DOI	10.2210/pdb1fs1/pdb
Related	1fqv 1fs2
Descriptor	CYCLIN A/CDK2-ASSOCIATED P19, CYCLIN A/CDK2-ASSOCIATED P45 (3 entities in total)
Functional Keywords	skp1, skp2, f-box, lrr, leucine-rich repeat, scf, ubiquitin, e3, ubiquitin protein ligase, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	44236.59
Authors	Schulman, B.A.,Carrano, A.C.,Jeffrey, P.D.,Bowen, Z.,Kinnucan, E.R.E.,Finnin, M.S.,Elledge, S.J.,Harper, J.W.,Pagano, M.,Pavletich, N.P. (deposition date: 2000-09-08, release date: 2000-11-29, Last modification date: 2024-02-07)
Primary citation	Schulman, B.A.,Carrano, A.C.,Jeffrey, P.D.,Bowen, Z.,Kinnucan, E.R.,Finnin, M.S.,Elledge, S.J.,Harper, J.W.,Pagano, M.,Pavletich, N.P. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature, 408:381-386, 2000 Cited by PubMed: 11099048 DOI: 10.1038/35042620 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation