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6FQU
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH DR09
Descriptor:CREB-binding protein, 1-[3-[3-[3,3-bis(fluoranyl)piperidin-1-yl]phenyl]-4-ethoxy-phenyl]ethanone
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-14
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FR0
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH PB08
Descriptor:CREB-binding protein, ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(2-ethyl-5-methyl-3-oxidanylidene-1,2-oxazol-4-yl)phenyl]furan-2-carboxamide
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-15
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FRF
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH PA10
Descriptor:CREB-binding protein, ~{N}-[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide
Authors:Zhu, J., Caflisch, A.
Deposit date:2018-02-15
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5LC5
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STRUCTURE OF MAMMALIAN RESPIRATORY COMPLEX I, CLASS2
Descriptor:NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, ...
Authors:Vinothkumar, K.R., Zhu, J., Hirst, J.
Deposit date:2016-06-19
Release date:2016-09-07
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (4.35 Å)
Cite:Structure of mammalian respiratory complex I.
Nature, 536, 2016
5LDW
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STRUCTURE OF MAMMALIAN RESPIRATORY COMPLEX I, CLASS1
Descriptor:NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, ...
Authors:Vinothkumar, K.R., Zhu, J., Hirst, J.
Deposit date:2016-06-28
Release date:2016-09-07
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.27 Å)
Cite:Structure of mammalian respiratory complex I.
Nature, 536, 2016
5LDX
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STRUCTURE OF MAMMALIAN RESPIRATORY COMPLEX I, CLASS3.
Descriptor:NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, ...
Authors:Vinothkumar, K.R., Zhu, J., Hirst, J.
Deposit date:2016-06-28
Release date:2016-09-14
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Structure of mammalian respiratory complex I.
Nature, 536, 2016
3UAT
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GUANYLATE KINASE DOMAINS OF THE MAGUK FAMILY SCAFFOLD PROTEINS AS SPECIFIC PHOSPHO-PROTEIN BINDING MODULES
Descriptor:Disks large homolog 1, phosphor-LGN peptide
Authors:Shang, Y., Zhu, J., Wen, W., Zhang, M.
Deposit date:2011-10-22
Release date:2011-12-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules
Embo J., 2011
4XEJ
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IRES BOUND TO BACTERIAL RIBOSOME
Descriptor:50S ribosomal protein L2, 50S ribosomal protein L3, 50S ribosomal protein L4, ...
Authors:Zhu, J., Korostelev, A., Noller, H.F., Donohue, J.P.
Deposit date:2014-12-23
Release date:2015-02-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Initiation of translation in bacteria by a structured eukaryotic IRES RNA.
Nature, 519, 2015
5B64
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A NOVEL BINDING MODE OF MAGUK GK DOMAIN REVEALED BY DLG GK DOMAIN IN COMPLEX WITH KIF13B MBS DOMAIN
Descriptor:DLG GK, Protein Kif13b, SULFATE ION, ...
Authors:Shang, Y., Zhu, J., Zhang, M.
Deposit date:2016-05-24
Release date:2016-10-12
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B
Structure, 24, 2016
5D7X
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CRYSTAL STRUCTURE OF THE HUMAN BRPF1 BROMODOMAIN IN COMPLEX WITH XZ08
Descriptor:Peregrin, NITRATE ION, 4-(1-acetyl-1H-indol-3-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one
Authors:Zhu, J., Caflisch, A.
Deposit date:2015-08-14
Release date:2016-05-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J.Med.Chem., 59, 2016
5MPZ
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH CBP007
Descriptor:CREB-binding protein, methyl 2-oxidanylidene-3~{H}-1,3-benzoxazole-6-carboxylate
Authors:Zhu, J., Spiliotopoulos, D., Caflisch, A.
Deposit date:2016-12-19
Release date:2017-05-10
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.
Bioorg. Med. Chem. Lett., 27, 2017
5MQE
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH CBP006
Descriptor:CREB-binding protein, 4-bromanyl-~{N}-methyl-1~{H}-pyrrole-2-carboxamide
Authors:Zhu, J., Spiliotopoulos, D., Caflisch, A.
Deposit date:2016-12-20
Release date:2017-04-19
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.
Bioorg. Med. Chem. Lett., 27, 2017
5MQG
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH CBP015
Descriptor:CREB-binding protein, 1-(4-azanyl-3-methoxy-phenyl)ethanone
Authors:Zhu, J., Spiliotopoulos, D., Caflisch, A.
Deposit date:2016-12-20
Release date:2017-04-19
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.
Bioorg. Med. Chem. Lett., 27, 2017
5MQK
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXED WITH CBP019
Descriptor:CREB-binding protein, 1-(1-methylindol-3-yl)ethanone
Authors:Zhu, J., Spiliotopoulos, D., Caflisch, A.
Deposit date:2016-12-20
Release date:2017-04-19
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain.
Bioorg. Med. Chem. Lett., 27, 2017
5NLK
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CRYSTAL STRUCTURE OF CREBBP BROMODOMAIN COMPLEXD WITH US13A
Descriptor:CREB-binding protein, ~{N}-[3-acetamido-5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]phenyl]furan-2-carboxamide
Authors:Zhu, J., Caflisch, A.
Deposit date:2017-04-04
Release date:2018-02-21
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).
ACS Cent Sci, 4, 2018
4JGD
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A016
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Zhu, J., Ren, X., Li, H.
Deposit date:2013-03-01
Release date:2014-03-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A016
TO BE PUBLISHED
4JS3
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 057
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Li, H., Zhu, J., Ren, X.
Deposit date:2013-03-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057
TO BE PUBLISHED
4JTS
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 072
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Zhu, J., Ren, X., Li, H.
Deposit date:2013-03-24
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057
To be Published
4JTT
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 066
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Li, H., Zhu, J., Ren, X.
Deposit date:2013-03-24
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057
TO BE PUBLISHED
4JTU
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH BREQUINAR ANALOGUE
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Zhu, J., Ren, X., Li, H.
Deposit date:2013-03-24
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 057
To be Published
4LS0
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH01B0033
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Li, H., Ren, X., Zhu, J.
Deposit date:2013-07-21
Release date:2014-07-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033
To be Published
4LS1
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A312
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Li, H., Ren, X., Zhu, J.
Deposit date:2013-07-21
Release date:2014-07-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312
To be Published
4LS2
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A313
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Li, H., Ren, X., Zhu, J.
Deposit date:2013-07-21
Release date:2014-07-23
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313
To be Published
4RK8
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A356
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Ren, X., Zhu, J., Li, H.
Deposit date:2014-10-12
Release date:2015-11-11
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356
TO BE PUBLISHED
4RKA
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH DH03A347
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhu, L., Ren, X., Zhu, J., Li, H.
Deposit date:2014-10-12
Release date:2015-11-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347
TO BE PUBLISHED