6FRF

Crystal structure of CREBBP bromodomain complexd with PA10

Summary for 6FRF

Entry DOI	10.2210/pdb6frf/pdb
Descriptor	CREB-binding protein, ~{N}-[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide (3 entities in total)
Functional Keywords	inhibitor, bromodomain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	58671.31
Authors	Zhu, J.,Caflisch, A. (deposition date: 2018-02-15, release date: 2018-08-29, Last modification date: 2024-01-17)
Primary citation	Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543 DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation