5MPN

Crystal structure of CREBBP bromodomain complexed with FA26

Summary for 5MPN

Entry DOI	10.2210/pdb5mpn/pdb
Descriptor	CREB-binding protein, 1-[4-ethoxy-3-[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]ethanone, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	crebbp bromodomain, inhibitor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14964.16
Authors	Zhu, J.,Caflisch, A. (deposition date: 2016-12-16, release date: 2018-01-17, Last modification date: 2019-10-16)
Primary citation	Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543 DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.23 Å)

Structure validation