Crystal structure of the human BRPF1 bromodomain in complex with BZ091

Summary for 5MWG

DescriptorPeregrin, ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide, NITRATE ION, ... (4 entities in total)
Functional Keywordsbromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight28434.59
Zhu, J.,Caflisch, A. (deposition date: 2017-01-18, release date: 2018-02-14, Last modification date: 2019-10-16)
Primary citation
Zhu, J.,Zhou, C.,Caflisch, A.
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155:337-352, 2018
PubMed: 29902720 (PDB entries with the same primary citation)
DOI: 10.1016/j.ejmech.2018.05.037
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22750 1.5% 0.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-09-16