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6UFR
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BU of 6ufr by Molmil
Structure of recombinantly assembled E46K alpha-synuclein fibrils
Descriptor: Alpha-synuclein
Authors:Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L.
Deposit date:2019-09-24
Release date:2020-02-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc.Natl.Acad.Sci.USA, 117, 2020
8DU2
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BU of 8du2 by Molmil
HnRNPA2 D290V LCD PM1
Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R.
Deposit date:2022-07-26
Release date:2023-08-02
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
8DUW
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BU of 8duw by Molmil
HnRNPA2 D290V LCD PM2
Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R.
Deposit date:2022-07-27
Release date:2023-08-02
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
8EC7
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BU of 8ec7 by Molmil
HnRNPA2 D290V LCD PM3
Descriptor: Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R.
Deposit date:2022-09-01
Release date:2023-09-06
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
6N4P
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BU of 6n4p by Molmil
RQEFEV, crystal structure of the N-terminal segment RQEFEV from protein tau
Descriptor: Microtubule-associated protein tau
Authors:Eisenberg, D.S, Boyer, D.R.
Deposit date:2018-11-19
Release date:2019-11-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:A structure-based model for the electrostatic interaction of the N-terminus of protein tau with the fibril core of Alzheimer's Disease filaments
Biorxiv, 2021
6ODG
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BU of 6odg by Molmil
SVQIVY, Crystal Structure of a tau protein fragment
Descriptor: Microtubule-associated protein tau
Authors:Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M.
Deposit date:2019-03-26
Release date:2019-10-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J.Biol.Chem., 294, 2019
4UNT
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BU of 4unt by Molmil
Induced monomer of the Mcg variable domain
Descriptor: IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION
Authors:Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C.M, Whitelegge, J.P, Phillips, M.L, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2014-05-30
Release date:2014-08-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains.
J.Biol.Chem., 289, 2014
5FOY
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BU of 5foy by Molmil
De novo structure of the binary mosquito larvicide BinAB at pH 7
Descriptor: 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN
Authors:Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S.
Deposit date:2015-11-26
Release date:2016-10-05
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
7SAS
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BU of 7sas by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
7SAQ
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BU of 7saq by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
7SAR
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BU of 7sar by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
4XFO
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BU of 4xfo by Molmil
Structure of an amyloid-forming segment TAVVTN from human Transthyretin
Descriptor: Amyloid-forming peptide TAVVTN
Authors:Saelices, L, Sawaya, M, Cascio, D, Eisenberg, D.S.
Deposit date:2014-12-27
Release date:2015-10-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
4XFN
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BU of 4xfn by Molmil
Structure of an Amyloid forming peptide AEVVFT from Human Transthyretin
Descriptor: Amyloid forming peptide AEVVFT
Authors:Saelices, L, Sawaya, M, Cascio, D, Eisenberg, D.S.
Deposit date:2014-12-27
Release date:2015-10-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
6PES
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BU of 6pes by Molmil
Cryo-EM structure of alpha-synuclein H50Q Wide Fibril
Descriptor: Alpha-synuclein
Authors:Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S.
Deposit date:2019-06-20
Release date:2019-11-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
6PIL
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BU of 6pil by Molmil
Antibody scFv-M204 monomeric state
Descriptor: CHLORIDE ION, scFv-M204 antibody
Authors:Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S.
Deposit date:2019-06-26
Release date:2020-06-24
Last modified:2020-08-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
6VW2
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BU of 6vw2 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils
Descriptor: Islet amyloid polypeptide (SUMO-tagged)
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2020-02-18
Release date:2020-06-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
Nat.Struct.Mol.Biol., 27, 2020
6WPQ
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BU of 6wpq by Molmil
GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant
Descriptor: Heterogeneous nuclear ribonucleoprotein A2
Authors:Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2020-04-27
Release date:2020-08-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
7ROJ
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BU of 7roj by Molmil
Amyloid-related segment of alphaB-crystallin residues 90-100 with G95W mutation
Descriptor: Alpha-crystallin B chain peptide, GLYCEROL, SODIUM ION, ...
Authors:Sawaya, M.R, Do, T.D, Eisenberg, D.S.
Deposit date:2021-07-30
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices.
Protein Sci., 31, 2022
7ROL
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BU of 7rol by Molmil
Amyloid-related segment of alphaB-crystallin residues 90-100 with G95W mutation, bromo derivative
Descriptor: Alpha-crystallin B chain peptide
Authors:Sawaya, M.R, Do, T.D, Eisenberg, D.S.
Deposit date:2021-07-30
Release date:2022-02-16
Last modified:2022-03-02
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices.
Protein Sci., 31, 2022
6WQK
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BU of 6wqk by Molmil
hnRNPA2 Low complexity domain (LCD) determined by cryoEM
Descriptor: MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera
Authors:Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2020-04-29
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
6AS9
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BU of 6as9 by Molmil
Filamentous Assembly of Green Fluorescent Protein Supported by a C-terminal fusion of 18-residues, viewed in space group P212121 form 2
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Green fluorescent protein
Authors:Sawaya, M.R, Heller, D.M, McPartland, L, Hochschild, A, Eisenberg, D.S.
Deposit date:2017-08-23
Release date:2018-05-30
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Atomic insights into the genesis of cellular filaments by globular proteins.
Nat. Struct. Mol. Biol., 25, 2018
6B79
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BU of 6b79 by Molmil
Curved pair of sheets formed from SOD1 residues 28-38 with familial mutation G37R.
Descriptor: 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid, Superoxide dismutase [Cu-Zn]
Authors:Sangwan, S, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2017-10-03
Release date:2018-05-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
Protein Sci., 27, 2018
6BCS
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BU of 6bcs by Molmil
LilrB2 D1D2 domains complexed with benzamidine
Descriptor: BENZAMIDINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Cao, Q, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2017-10-20
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Nat Chem, 10, 2018
4ZNN
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BU of 4znn by Molmil
MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56
Descriptor: Alpha-synuclein
Authors:Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S.
Deposit date:2015-05-05
Release date:2015-09-09
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.41 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
5ACM
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BU of 5acm by Molmil
Mcg immunoglobulin variable domain with methylene blue
Descriptor: 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ...
Authors:Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2015-08-17
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain.
Elife, 4, 2015

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