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5VV8
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINOQUINOLIN-7-YL)METHYL)AMINO)ETHYL)-2-METHYLBENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5VV9
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINO-4-METHYLQUINOLIN-7-YL)METHYL)AMINO)ETHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5VVA
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINO-4-METHYLQUINOLIN-7-YL)METHYL)AMINO)ETHYL)-2-METHYLBENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5VVB
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STRUCTURE OF HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINOQUINOLIN-7-YL)METHYL)AMINO)ETHYL)-2-METHYLBENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5VVD
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STRUCTURE OF HUMAN ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINO-4-METHYLQUINOLIN-7-YL)METHYL)AMINO)ETHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5VVG
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINOQUINOLIN-7-YL)METHYL)AMINO)ETHYL)-2-CHLOROBENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5VVN
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(((2-AMINOQUINOLIN-7-YL)METHYL)AMINO)ETHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-05-19
Release date:2017-08-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60, 2017
5XFN
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STRUCTURE OF THE N-TERMINAL DOMAINS OF PHF1
Descriptor:PHD finger protein 1, ZINC ION
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFO
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STRUCTURE OF THE N-TERMINAL DOMAINS OF PHF1
Descriptor:PHD finger protein 1, ZINC ION
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFP
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BINARY COMPLEX OF PHF1 AND A DOUBLE STRANDED DNA
Descriptor:PHD finger protein 1, DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), ZINC ION, ...
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFQ
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TERNARY COMPLEX OF PHF1, A DNA DUPLEX AND A HISTONE PEPTIDE
Descriptor:PHD finger protein 1, DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), Peptide from Histone H3, ...
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFR
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TERNARY COMPLEX OF MTF2, DNA AND HISTONE
Descriptor:Metal-response element-binding transcription factor 2, Peptide from Histone H3.1, DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), ...
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
6AUQ
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(3-(3-(METHYLAMINO)PROPYL)PHENETHYL)PYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUR
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(3-FLUORO-5-(3-(METHYLAMINO)PROPYL)PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUS
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-(3-(METHYLAMINO)PROPYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUT
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(3-(3-(DIMETHYLAMINO)PROPYL)-5-FLUOROPHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUU
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(3-(3-(DIMETHYLAMINO)PROPYL)-5-(TRIFLUOROMETHYL)PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUV
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(3-((METHYLAMINO)METHYL)PHENYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUW
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(4-((METHYLAMINO)METHYL)PHENYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUX
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-FLUORO-3'-((METHYLAMINO)METHYL)-[1,1'-BIPHENYL]-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUY
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE R354A/G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(3-(3-(METHYLAMINO)PROPYL)PHENETHYL)PYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AUZ
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE R354A/G357D MUTANT HEME DOMAIN IN COMPLEX WITH 6-(3-FLUORO-5-(3-(METHYLAMINO)PROPYL)PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AV0
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE R354A/G357D MUTANT HEME DOMAIN IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)-5-(3-(METHYLAMINO)PROPYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:LI, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AV1
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE R354A/G357D MUTANT HEME DOMAIN IN COMPLEX WITH 6-(3-(3-(DIMETHYLAMINO)PROPYL)-5-FLUOROPHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017
6AV2
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE R354A/G357D MUTANT HEME DOMAIN IN COMPLEX WITH 6-(3-(3-(DIMETHYLAMINO)PROPYL)-5-(TRIFLUOROMETHYL)PHENETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-09-01
Release date:2018-07-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
J. Med. Chem., 60, 2017