5FMG

Structure and function based design of Plasmodium-selective proteasome inhibitors

Summary for 5FMG

Entry DOI	10.2210/pdb5fmg/pdb
EMDB information	3231
Descriptor	PROTEASOME SUBUNIT ALPHA, PUTATIVE, BETA3 PROTEASOME SUBUNIT, PUTATIVE, PROTEASOME SUBUNIT BETA TYPE, ... (15 entities in total)
Functional Keywords	hydrolase, proteasome, 20s, plasmodium, malaria, inhibitor, drug design, cryo-em
Biological source	PLASMODIUM FALCIPARUM More
Cellular location	Nucleus : Q8IAR3 C6KST3 Q8IK90 O77396 Cytoplasm . Nucleus : Q8I261 Q8IKC9 Q8IJT1 C0H4E8 Q7K6A9 Q8IDG3 Q8IDG2 Q8IBI3 Q8I6T3
Total number of polymer chains	28
Total formula weight	764272.01
Authors	Li, H.,O'Donoghue, A.J.,van der Linden, W.A.,Xie, S.C.,Yoo, E.,Foe, I.T.,Tilley, L.,Craik, C.S.,da Fonseca, P.C.A.,Bogyo, M. (deposition date: 2015-11-04, release date: 2016-03-02, Last modification date: 2017-08-23)
Primary citation	Li, H.,O'Donoghue, A.J.,Van Der Linden, W.A.,Xie, S.C.,Yoo, E.,Foe, I.T.,Tilley, L.,Craik, C.S.,Da Fonseca, P.C.A.,Bogyo, M. Structure and Function Based Design of Plasmodium-Selective Proteasome Inhibitors Nature, 530:233-, 2016 Cited by PubMed: 26863983 DOI: 10.1038/NATURE16936 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation