5FMG
Structure and function based design of Plasmodium-selective proteasome inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | PROTEASOME SUBUNIT ALPHA, PUTATIVE | polymer | 260 | 29531.7 | 2 | UniProt (Q8IAR3) Pfam (PF10584) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 2 | B, P (B, P) | PROTEASOME SUBUNIT ALPHA TYPE 2, PUTATIVE | polymer | 235 | 26556.4 | 2 | UniProt (C6KST3) Pfam (PF10584) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 3 | C, Q (C, Q) | PROTEASOME SUBUNIT ALPHA TYPE | polymer | 246 | 27977.7 | 2 | UniProt (Q8IDG3) Pfam (PF10584) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 4 | D, R (D, R) | PROTEASOME SUBUNIT ALPHA TYPE | polymer | 241 | 27263.3 | 2 | UniProt (Q8IDG2) Pfam (PF10584) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 5 | E, S (E, S) | PROTEASOME SUBUNIT ALPHA TYPE | polymer | 256 | 28417.4 | 2 | UniProt (Q8IBI3) Pfam (PF00227) Pfam (PF10584) | PLASMODIUM FALCIPARUM | |
| 6 | F, T (F, T) | PROTEOSOME SUBUNIT ALPHA TYPE 1, PUTATIVE | polymer | 254 | 28871.7 | 2 | UniProt (Q8IK90) Pfam (PF10584) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 7 | G, U (G, U) | PROTEASOME COMPONENT C8, PUTATIVE | polymer | 252 | 29324.3 | 2 | UniProt (O77396) Pfam (PF10584) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 8 | H, V (H, V) | PROTEASOME, PUTATIVE | polymer | 252 | 29143.9 | 2 | UniProt (Q8I0U7) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 9 | I, W (I, W) | PROTEASOME SUBUNIT BETA TYPE | polymer | 229 | 25104.9 | 2 | UniProt (Q8I6T3) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 10 | J, X (J, X) | BETA3 PROTEASOME SUBUNIT, PUTATIVE | polymer | 218 | 24533.1 | 2 | UniProt (Q8I261) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 11 | K, Y (K, Y) | PROTEASOME SUBUNIT BETA TYPE | polymer | 195 | 22889.1 | 2 | UniProt (Q8IKC9) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 12 | L, Z (L, Z) | PROTEASOME SUBUNIT BETA TYPE | polymer | 211 | 23620.6 | 2 | UniProt (Q8IJT1) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 13 | AA, M (M, a) | PROTEASOME SUBUNIT BETA TYPE | polymer | 240 | 27301.2 | 2 | UniProt (C0H4E8) | PLASMODIUM FALCIPARUM | |
| 14 | BA, N (N, b) | PROTEASOME SUBUNIT BETA TYPE | polymer | 265 | 30909.9 | 2 | UniProt (Q7K6A9) Pfam (PF00227) | PLASMODIUM FALCIPARUM | |
| 15 | CA, DA (I, W) | (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide | non-polymer | 690.9 | 2 | Chemie (7F1) |
Sequence modifications
J, X: 15 - 218 (UniProt: Q8I261)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Ile 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Asn 6 | - | expression tag |
| Tyr 7 | - | expression tag |
| Asn 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Cys 11 | - | expression tag |
| Val 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Gly 14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 762890.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1381.7 | |
| All* | Total formula weight | 764272.0 |
