4CX7

Structure of human iNOS heme domain in complex with (R)-6-(3-AMINO-2-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)PROPYL)-4- METHYLPYRIDIN-2-AMINE

Summary for 4CX7

Entry DOI	10.2210/pdb4cx7/pdb
Related	4CWV 4CWW 4CWX 4CWY 4CWZ 4CX0 4CX1 4CX2 4CX3 4CX4 4CX5 4CX6
Descriptor	NITRIC OXIDE SYNTHASE, INDUCIBLE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywords	oxidoreductase, inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	4
Total formula weight	204992.00
Authors	Li, H.,Poulos, T.L. (deposition date: 2014-04-03, release date: 2014-08-13, Last modification date: 2023-12-20)
Primary citation	Li, H.,Jamal, J.,Delker, S.L.,Plaza, C.,Ji, H.,Jing, Q.,Huang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L. Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases. Biochemistry, 53:5272-, 2014 Cited by PubMed: 25089924 DOI: 10.1021/BI500561H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation