4CWV

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL)PENTYL)OXY) PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

Summary for 4CWV

Entry DOI	10.2210/pdb4cwv/pdb
Related	4CWW 4CWX 4CWY 4CWZ 4CX0 4CX1 4CX2 4CX3 4CX4 4CX5 4CX6 4CX7
Descriptor	NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	oxidoreductase, nitric oxide synthase, inhibitor complex
Biological source	BOS TAURUS (CATTLE)
Cellular location	Cell membrane: P29473
Total number of polymer chains	2
Total formula weight	102061.97
Authors	Li, H.,Poulos, T.L. (deposition date: 2014-04-03, release date: 2014-08-13, Last modification date: 2014-09-03)
Primary citation	Li, H.,Jamal, J.,Delker, S.L.,Plaza, C.,Ji, H.,Jing, Q.,Huang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L. Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases. Biochemistry, 53:5272-, 2014 Cited by PubMed: 25089924 DOI: 10.1021/BI500561H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation