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5A78
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA NOT CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP *CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5ME8
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5
Descriptor:Inhibitor of growth protein 5, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL
Authors:Roversi, P., Blanco, F.J., Rojas, A.L., Buitrago, J.A.R.
Deposit date:2016-11-14
Release date:2018-03-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The tumor suppressor ING5 is a dimeric molecule with Bivalent Recognition of the H3K4me3 mark
To Be Published
5MTO
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT
Descriptor:Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:N-terminal domain of the human tumor suppressor ING5 C19S mutant
To Be Published
6GWS
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE P15 PEPTIDES
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor
Authors:De March, M., Merino, N., Gonzalez-Magana, A., Romano-Moreno, M., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2018-06-25
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
6HVO
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE PEPTIDES OF P12 SUBUNIT OF HUMAN POLYMERASE DELTA
Descriptor:Proliferating cell nuclear antigen, DNA polymerase delta subunit 4, SULFATE ION
Authors:Gonzalez-Magana, A., Romano-Moreno, M., Rojas, A.L., Blanco, F.J., De Biasio, A.
Deposit date:2018-10-11
Release date:2019-01-23
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The p12 subunit of human polymerase delta uses an atypical PIP-box for molecular recognition of proliferating cell nuclear antigen (PCNA).
J. Biol. Chem., 2019
2K2X
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SOLUTION STRUCTURE OF TICK CARBOXYPEPTIDASE INHIBITOR AT PH 3.5
Descriptor:Carboxypeptidase inhibitor
Authors:Pantoja-Uceda, D., Blanco, F.
Deposit date:2008-04-15
Release date:2009-01-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways.
J.Biol.Chem., 283, 2008
2K2Y
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SOLUTION STRUCTURE OF THE FOLDED DOMAIN OF INTERMEDIATE IIIA OF TICK CARBOXYPEPTIDASE INHIBITOR
Descriptor:Carboxypeptidase inhibitor
Authors:Pantoja-Uceda, D., Blanco, F.
Deposit date:2008-04-15
Release date:2009-01-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways.
J.Biol.Chem., 283, 2008
2K2Z
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SOLUTION STRUCTURE OF THE FOLDED DOMAIN OF INTERMEDIATE IIIB OF TICK CARBOXYPEPTIDASE INHIBITOR
Descriptor:Carboxypeptidase inhibitor
Authors:Pantoja-Uceda, D., Blanco, F.
Deposit date:2008-04-15
Release date:2009-01-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR structures of the major intermediates of the two-domain tick carboxypeptidase inhibitor reveal symmetry in its folding and unfolding pathways.
J.Biol.Chem., 283, 2008
1TUC
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ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT S19-P20
Descriptor:ALPHA-SPECTRIN
Authors:Wilmanns, M., Serrano, L., Viguera, A.R.
Deposit date:1996-02-29
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The order of secondary structure elements does not determine the structure of a protein but does affect its folding kinetics.
J.Mol.Biol., 247, 1995
1TUD
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ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48
Descriptor:ALPHA-SPECTRIN
Authors:Viguera, A.R., Serrano, L., Wilmanns, M.
Deposit date:1996-02-29
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:The order of secondary structure elements does not determine the structure of a protein but does affect its folding kinetics.
J.Mol.Biol., 247, 1995
2KPZ
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HUMAN NEDD4 3RD WW DOMAIN COMPLEX WITH THE HUMAN T-CELL LEUKEMIA VIRUS 1 GAG-PRO POLIPROTEIN DERIVED PEPTIDE SDPQIPPPYVEP
Descriptor:E3 ubiquitin-protein ligase NEDD4, 12-mer from Gag-Pro polyprotein
Authors:Iglesias-Bexiga, M., Macias, M., Bonet, R., Blanco, F.J., Cobos, E.S., Luque, I.
Deposit date:2009-10-23
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Human NEDD4 3RD WW Domain Complex with Human T-cell Leukemia virus GAP-Pro Poliprotein Derived Peptide
To be Published
2KQ0
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HUMAN NEDD4 3RD WW DOMAIN COMPLEX WITH EBOLA ZAIRE VIRUS MATRIX PROTEIN VP40 DERIVED PEPTIDE ILPTAPPEYMEA
Descriptor:E3 ubiquitin-protein ligase NEDD4, 12-mer from Matrix protein VP40
Authors:Iglesias-Bexiga, M., Macias, M., Bonet, R., Blanco, F.J., Cobos, E.S., Luque, I.
Deposit date:2009-10-23
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide
To be Published
2OTT
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CRYSTAL STRUCTURE OF CD5_DIII
Descriptor:T-cell surface glycoprotein CD5
Authors:Rodamilans, B.
Deposit date:2007-02-09
Release date:2007-03-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.
J.Biol.Chem., 282, 2007
3MX9
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:Protein scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*CP*CP*TP*GP*AP*GP*AP*AP*CP*AP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXA
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXB
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:V3(E8K), V2(K7E-G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
6FB0
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF CALCIUM
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*GP*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB1
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (3.024 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB2
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF MANGANESE
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB5
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) AT 5NNN REGION IN THE PRESENCE OF MAGNESIUM
Descriptor:I-CreI monomer A, I-CreI monomer B, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB6
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) AT 5NNN REGION IN THE PRESENCE OF MANGANESE
Descriptor:I-CreI monomer A, I-CreI monomer B, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*C)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB7
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MANGANESE
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.689 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB8
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA AT 5NNN REGION IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP*GP*CP*AP*GP*TP*TP*TP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB9
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA AT 5NNN REGION IN THE PRESENCE OF MANGANESE
Descriptor:DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*C)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
1TRL
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NMR SOLUTION STRUCTURE OF THE C-TERMINAL FRAGMENT 255-316 OF THERMOLYSIN: A DIMER FORMED BY SUBUNITS HAVING THE NATIVE STRUCTURE
Descriptor:THERMOLYSIN FRAGMENT 255 - 316
Authors:Rico, M., Jimenez, M.A., Gonzalez, C., De Filippis, V., Fontana, A.
Deposit date:1994-09-02
Release date:1995-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR solution structure of the C-terminal fragment 255-316 of thermolysin: a dimer formed by subunits having the native structure.
Biochemistry, 33, 1994