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5FFG
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CRYSTAL STRUCTURE OF INTEGRIN ALPHA V BETA 6 HEAD
Descriptor:Integrin alpha-V, Integrin beta-6, CALCIUM ION, ...
Authors:Dong, X., Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
5FFO
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INTEGRIN ALPHA V BETA 6 IN COMPLEX WITH PRO-TGF-BETA
Descriptor:Integrin alpha-V, Integrin beta-6, Transforming growth factor beta-1, ...
Authors:Dong, X., Zhao, B., Springer, T.A.
Deposit date:2015-12-18
Release date:2017-01-25
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
5HDB
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INTEGRIN ALPHAIIBBETA3 IN COMPLEX WITH RO-435054
Descriptor:Integrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ...
Authors:Lin, F.Y.
Deposit date:2016-01-05
Release date:2016-02-03
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.7012 Å)
Cite:beta-Subunit Binding Is Sufficient for Ligands to Open the Integrin alpha IIb beta 3 Headpiece.
J.Biol.Chem., 291, 2016
5JS9
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 8-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (6.918 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JSA
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 10-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (6.308 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5QBV
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CRYSTAL STRUCTURE OF HUMAN CATHEPSIN-S WITH BOUND LIGAND
Descriptor:Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzyl]benzamide
Authors:Bembenek, S.D., Ameriks, M.K., Mirzadegan, T., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
Bioorg.Med.Chem.Lett., 20, 2010
5QBY
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CRYSTAL STRUCTURE OF HUMAN CATHEPSIN-S WITH BOUND LIGAND
Descriptor:Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyrimidin-5-yl)benzyl]-4-fluorobenzamide
Authors:Bembenek, S.D., Ameriks, M.K., Mirzadegan, T., Yang, H., Shao, C., Burley, S.K.
Deposit date:2017-08-04
Release date:2017-12-20
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
Bioorg.Med.Chem.Lett., 20, 2010
5VNZ
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STRUCTURE OF A TRAF6-UBC13~UB COMPLEX
Descriptor:TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, Ubiquitin, ...
Authors:Middleton, A.J., Day, C.L.
Deposit date:2017-05-01
Release date:2017-12-06
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.
Nat Commun, 8, 2017
5VO0
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STRUCTURE OF A TRAF6-UBC13~UB COMPLEX
Descriptor:TNF receptor-associated factor 6, Ubiquitin-conjugating enzyme E2 N, Ubiquitin, ...
Authors:Middleton, A.J., Day, C.L.
Deposit date:2017-05-01
Release date:2017-12-06
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.
Nat Commun, 8, 2017
5XV7
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SRPK1 IN COMPLEX WITH ALECTINIB
Descriptor:serine-arginine (SR) protein kinase 1, 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Authors:Zeng, C., Ngo, J.C.K.
Deposit date:2017-06-26
Release date:2018-03-14
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Cell Chem Biol, 25, 2018
6BZU
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY 19B3
Descriptor:19B3 Heavy Chain, 19B3 Light Chain, E2 AS412 peptide
Authors:Tzarum, N., Alemn, F., Kong, L., Wilson, I.A., Law, M.
Deposit date:2017-12-26
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BZV
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE GL PRECURSOR OF THE BROADLY NEUTRALIZING ANTIBODY 19B3
Descriptor:19B3 GL Heavy Chain, 19B3 GL Light Chain, E2 AS412 peptide
Authors:Tzarum, N., Alemn, F., Wilson, I.A., Law, M.
Deposit date:2017-12-26
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.654 Å)
Cite:Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BZW
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE GL PRECURSOR OF THE BROADLY NEUTRALIZING ANTIBODY AP33
Descriptor:AP33 GL Heavy Chain, AP33 GL Light Chain, E2 AS412 peptide
Authors:Tzarum, N., Alemn, F., Wilson, I.A., Law, M.
Deposit date:2017-12-26
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BZY
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 412-423 BOUND TO THE 22D11 BROADLY NEUTRALIZING ANTIBODY
Descriptor:22D11 Heavy Chain, 22D11 Light Chain, E2 AS412 peptide
Authors:Tzarum, N., Alemn, F., Wilson, I.A., Law, M.
Deposit date:2017-12-26
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6QV5
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CRYSTAL STRUCTURE OF THE CHAD DOMAIN FROM THE PLANT RICINUS COMMUNIS
Descriptor:CHAD domain, ZINC ION, 1,2-ETHANEDIOL
Authors:Lorenzo-Orts, L., Hothorn, M.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules.
Life Sci Alliance, 2, 2019
6QV7
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CRYSTAL STRUCTURE OF A CHAD DOMAIN FROM CHLOROBIUM TEPIDUM
Descriptor:Uncharacterized protein, ISOPROPYL ALCOHOL, 1,2-ETHANEDIOL, ...
Authors:Lorenzo-Orts, L., Hothorn, M.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules.
Life Sci Alliance, 2, 2019
6QVA
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CRYSTAL STRUCTURE OF A CHAD DOMAIN FROM CHLOROBIUM TEPIDUM IN COMPLEX WITH INORGANIC POLYPHOSPHATE
Descriptor:CHAD domain, 1,2-ETHANEDIOL, bis[oxidanyl-[oxidanyl-[oxidanyl(phosphonooxy)phosphoryl]oxy-phosphoryl]oxy-phosphoryl] hydrogen phosphate, ...
Authors:Lorenzo-Orts, L., Hothorn, M.
Deposit date:2019-03-01
Release date:2019-05-29
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules.
Life Sci Alliance, 2, 2019
5VQF
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CRYSTAL STRUCTURE OF PRO-TGF-BETA 1
Descriptor:Transforming growth factor beta-1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Zhao, B., Xu, S., Dong, X., Lu, C., Springer, T.A.
Deposit date:2017-05-08
Release date:2017-11-15
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018
4JPW
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 12A21 IN COMPLEX WITH HIV-1 STRAIN 93TH057 GP120 MUTANT
Descriptor:HIV-1 CLADE A/E STRAIN 73TH057 GP120 WITH MUTATION H375S, HEAVY CHAIN OF ANTIBODY 12A21, LIGHT CHAIN OF ANTIBODY 12A21, ...
Authors:Acharya, P., Luongo, T., Zhou, T., Kwong, P.D.
Deposit date:2013-03-19
Release date:2013-04-17
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.904 Å)
Cite:Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell(Cambridge,Mass.), 153, 2013