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3JC5
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STRUCTURE OF THE EUKARYOTIC REPLICATIVE CMG HELICASE AND PUMPJACK MOTION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Bai, L., Yuan, Z., Sun, J., Georgescu, R.E., Liu, J., O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC6
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STRUCTURE OF THE EUKARYOTIC REPLICATIVE CMG HELICASE AND PUMPJACK MOTION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Bai, L., Yuan, Z., Sun, J., Georgescu, R.E., Liu, J., O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC7
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STRUCTURE OF THE EUKARYOTIC REPLICATIVE CMG HELICASE AND PUMPJACK MOTION
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Bai, L., Yuan, Z., Sun, J., Georgescu, R.E., Liu, J., O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JT3
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N~5~-[2-(METHYLSULFANYL)ETHANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JT4
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N~5~-[(3-(ETHYLSULFANYL)PROPANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JT5
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N~5~-[2-(ETHYLSULFANYL)ETHANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JT6
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N~5~-[4-(METHYLSULFANYL)BUTANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JT7
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N~5~-[2-(PROPYLSULFANYL)ETHANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JT8
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N~5~-{3-[(1-METHYLETHYL)SULFANYL]PROPANIMIDOYL}-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JT9
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN THE FERROUS STATE COMPLEXED WITH N~5~-[2-(ETHYLSULFANYL)ETHANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3JTA
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN THE FERROUS STATE COMPLEXED WITH N~5~-[4-(METHYLSULFANYL)BUTANIMIDOYL]-L-ORNITHINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2009-09-11
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron-thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency.
J.Am.Chem.Soc., 132, 2010
3M9B
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CRYSTAL STRUCTURE OF THE AMINO TERMINAL COILED COIL DOMAIN AND THE INTER DOMAIN OF THE MYCOBACTERIUM TUBERCULOSIS PROTEASOMAL ATPASE MPA
Descriptor:Proteasome-associated ATPase
Authors:Li, H., Wang, T.
Deposit date:2010-03-21
Release date:2010-10-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.94 Å)
Cite:Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.
Nat.Struct.Mol.Biol., 17, 2010
3M9D
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CRYSTAL STRUCTURE OF THE PROKARYOTIC UBIQUINTIN-LIKE PROTEIN PUP COMPLEXED WITH THE HEXAMERIC PROTEASOMAL ATPASE MPA WHICH INCLUDES THE AMINO TERMINAL COILED COIL DOMAIN AND THE INTER DOMAIN
Descriptor:Proteasome-associated ATPase, Prokaryotic ubiquitin-like protein pup
Authors:Li, H., Wang, T.
Deposit date:2010-03-22
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.
Nat.Struct.Mol.Biol., 17, 2010
3M9H
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CRYSTAL STRUCTURE OF THE AMINO TERMINAL COILED COIL DOMAIN OF THE MYCOBACTERIUM TUBERCULOSIS PROTEASOMAL ATPASE MPA
Descriptor:Proteasome-associated ATPase
Authors:Li, H., Wang, T.
Deposit date:2010-03-22
Release date:2010-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.
Nat.Struct.Mol.Biol., 17, 2010
3N5V
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(3-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PHENETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5W
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5X
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6-(2-{5-[2-(2-amino-6-methylpyridin-4-yl)ethyl]pyridin-3-yl}ethyl)-4-methylpyridin-2-amine, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5Y
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-2,6-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N5Z
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-(2-(6-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-2-YL)ETHYL)-6-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N60
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N61
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N62
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-(pyridine-3,5-diyldiethane-2,1-diyl)bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N63
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N/M336V MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N64
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE D597N MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(5-AMINO-1,3-PHENYLENE)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 6,6'-[(5-aminobenzene-1,3-diyl)diethane-2,1-diyl]bis(4-methylpyridin-2-amine), ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010
3N65
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE S602H MUTANT HEME DOMAIN IN COMPLEX WITH 6,6'-(2,2'-(PYRIDINE-3,5-DIYL)BIS(ETHANE-2,1-DIYL))BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Delker, S.L., Poulos, T.L.
Deposit date:2010-05-25
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
Biochemistry, 49, 2010