8SMV
| GPR161 Gs heterotrimer | Descriptor: | CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Hoppe, N, Manglik, A, Harrison, S. | Deposit date: | 2023-04-26 | Release date: | 2024-02-21 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Biorxiv, 2023
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8CXO
| Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment | Descriptor: | CHOLESTEROL, Smoothened homolog, GlgA glycogen synthase chimera | Authors: | Zhang, K, Wu, H, Hoppe, N, Manglik, A, Cheng, Y. | Deposit date: | 2022-05-22 | Release date: | 2022-08-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun, 13, 2022
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7KKL
| SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | Deposit date: | 2020-10-27 | Release date: | 2020-11-11 | Last modified: | 2021-04-21 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370, 2020
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7KKK
| SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | Deposit date: | 2020-10-27 | Release date: | 2020-11-11 | Last modified: | 2021-04-21 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370, 2020
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7T32
| CryoEM structure of the adenosine 2A receptor-BRIL/Anti BRIL Fab complex with ZM241385 | Descriptor: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 Fusion Protein | Authors: | Zhang, K.H, Wu, H, Hoppe, N, Manglik, A, Cheng, Y.F. | Deposit date: | 2021-12-06 | Release date: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nat Commun, 13, 2022
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7KKJ
| Structure of anti-SARS-CoV-2 Spike nanobody mNb6 | Descriptor: | CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6 | Authors: | Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium | Deposit date: | 2020-10-27 | Release date: | 2020-11-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science, 370, 2020
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7KDT
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7T9I
| Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ... | Authors: | Faust, B, Cheng, Y, Manglik, A. | Deposit date: | 2021-12-19 | Release date: | 2022-08-03 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7T9N
| M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Faust, B, Cheng, Y, Manglik, A. | Deposit date: | 2021-12-19 | Release date: | 2022-08-03 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7T9M
| Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS-17 Heavy Chain, ... | Authors: | Faust, B, Cheng, Y, Manglik, A. | Deposit date: | 2021-12-19 | Release date: | 2022-08-10 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7UTZ
| Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ... | Authors: | Faust, B, Cheng, Y, Manglik, A. | Deposit date: | 2022-04-28 | Release date: | 2022-08-03 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature, 609, 2022
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7K1A
| TtgR quadruple mutant (C137I I141W M167L F168Y) | Descriptor: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION | Authors: | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | Deposit date: | 2020-09-07 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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7KD8
| TtgR C137I I141W M167L F168Y mutant in complex with resveratrol | Descriptor: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL | Authors: | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | Deposit date: | 2020-10-08 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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7K1C
| TtgR in complex with resveratrol | Descriptor: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL | Authors: | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | Deposit date: | 2020-09-07 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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