PDB: 339 件ウェブページステータス検索Chemie searchBIRD

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2XYH	Caspase-3:CAS60254719 分子名称: 5-CHLORO-4-OXOPENTANOIC ACID, CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17 著者 Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R. 登録日 2010-11-17 公開日 2011-08-17 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety. Acta Crystallogr.,Sect.F, 67, 2011
2Y1L	Caspase-8 in Complex with DARPin-8.4 分子名称: 1,2-ETHANEDIOL, AC-IETD-CHO, CASPASE-8, ... 著者 Barandun, J, Schroeder, T, Mittl, P.R.E, Grutter, M.G. 登録日 2010-12-08 公開日 2011-12-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Caspase-8 in Complex with Darpin-8.4 To be Published
1NMS	Caspase-3 tethered to irreversible inhibitor 分子名称: 5-[4-(1-CARBOXYMETHYL-2-OXO-PROPYLCARBAMOYL)-BENZYLSULFAMOYL]-2-HYDROXY-BENZOIC ACID, Caspase-3 著者 Erlanson, D.A, Lam, J, Wiesmann, C, Luong, T.N, Simmons, R.L, DeLano, W.L, Choong, I.C, Flanagan, W.M, Lee, D, O'Brian, T. 登録日 2003-01-10 公開日 2003-03-11 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 In situ assembly of enzyme inhibitors using extended tethering. Nat.Biotechnol., 21, 2003
1NMQ	Extendend Tethering: In Situ Assembly of Inhibitors 分子名称: 3-(3-{2-[(5-METHANESULFONYL-THIOPHENE-2-CARBONYL)-AMINO]-ETHYLDISULFANYLMETHYL}- BENZENESULFONYLAMINO)-4-OXO-PENTANOIC ACID, Caspase-3 著者 Erlanson, D.A, Lam, J, Wiesmann, C, Luong, T.N, Simmons, R.L, DeLano, W, Choong, I.C, Flanagan, M, Lee, D, O'Brian, T. 登録日 2003-01-10 公開日 2003-03-11 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 In situ assembly of enzyme inhibitors using extended tethering. Nat.Biotechnol., 21, 2003
1PAU	Crystal structure of the complex of apopain with the tetrapeptide aldehyde inhibitor AC-DEVD-CHO 分子名称: ACE-ASP-GLU-VAL-ASJ, APOPAIN 著者 Rotonda, J, Becker, J.W. 登録日 1996-06-06 公開日 1997-07-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat.Struct.Biol., 3, 1996
3BIJ	Crystal structure of protein GSU0716 from Geobacter sulfurreducens. Northeast Structural Genomics target GsR13 分子名称: Uncharacterized protein GSU0716 著者 Forouhar, F, Neely, H, Su, M, Seetharaman, J, Benach, J, Conover, K, Fang, Y, Xiao, R, Owen, L.A, Maglaqui, M, Cunningham, K, Baran, M.C, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2007-11-30 公開日 2007-12-11 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of protein GSU0716 from Geobacter sulfurreducens. To be Published
1PYO	Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho 分子名称: ACETYL-LEU-ASP-GLU-SER-ASJ, Caspase-2 著者 Schweizer, A, Briand, C, Grutter, M.G. 登録日 2003-07-09 公開日 2003-08-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J.Biol.Chem., 278, 2003
6NS7	Crystal structure of murine caspase-11 分子名称: Caspase-11, SULFATE ION 著者 Yang, J, Liu, Z, Xiao, T.S. 登録日 2019-01-24 公開日 2020-07-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of murine caspase-11 To Be Published
6NRY	Crystal structure of human caspase-4 分子名称: Caspase-4, GLYCEROL 著者 Yang, J, Liu, Z, Shi, W, Xiao, T.S. 登録日 2019-01-24 公開日 2020-07-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.184 Å) 主引用文献 Crystal structure of human caspase-4 To Be Published
1QDU	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK 分子名称: CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR 著者 Blanchard, H, Grutter, M.G. 登録日 1999-07-10 公開日 2000-07-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure Fold.Des., 7, 1999
3DEH	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 分子名称: Caspase-3, isoquinoline-1,3,4(2H)-trione 著者 Wu, J, Du, J, Li, J, Ding, J. 登録日 2008-06-10 公開日 2008-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
1IBC	CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME 分子名称: INTERLEUKIN-1BETA CONVERTING ENZYME, PEPTIDE ACE-TRP-GLU-HIS-ASA 著者 Becker, J.W, Rotonda, J. 登録日 1997-02-12 公開日 1998-02-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem.Biol., 4, 1997
1ICE	STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME 分子名称: INTERLEUKIN-1 BETA CONVERTING ENZYME, TETRAPEPTIDE ALDEHYDE 著者 Wilson, K.P, Griffith, J.P, Kim, E.E, Navia, M.A. 登録日 1994-09-29 公開日 1995-07-28 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and mechanism of interleukin-1 beta converting enzyme. Nature, 370, 1994
3EDR	The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO 分子名称: Caspase-7, Inhibitor Ac-ldesd-cho peptide 著者 Agniswamy, J. 登録日 2008-09-03 公開日 2008-10-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008
3EDQ	Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO 分子名称: AC-LDESD-CHO peptide, Caspase-3 著者 Fu, G. 登録日 2008-09-03 公開日 2008-10-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008
3D6F	Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published
3D6M	Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3D6H	Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3DEJ	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 分子名称: (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 著者 Wu, J, Du, J, Li, J, Ding, J. 登録日 2008-06-10 公開日 2008-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
3V6L	Crystal Structure of caspase-6 inactivation mutation 分子名称: Caspase-6 著者 Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. 登録日 2011-12-20 公開日 2012-03-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287, 2012
3V6M	Inhibition of caspase-6 activity by single mutation outside the active site 分子名称: Caspase-6 著者 Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D. 登録日 2011-12-20 公開日 2012-03-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.692 Å) 主引用文献 Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays J.Biol.Chem., 287, 2012
1K86	Crystal structure of caspase-7 分子名称: caspase-7 著者 Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. 登録日 2001-10-23 公開日 2001-11-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001
3V4O	Human MALT1 (caspase domain) in complex with an irreversible peptidic inhibitor 分子名称: MALT1 Inhibitor, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 著者 Renatus, M, Wiesmann, C. 登録日 2011-12-15 公開日 2012-03-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Determinants of MALT1 Protease Activity. J.Mol.Biol., 419, 2012
1JXQ	Structure of cleaved, CARD domain deleted Caspase-9 分子名称: Caspase-9, benzoxycarbonyl-Val-Ala-Asp-fluoromethyl ketone Inhibitor 著者 Renatus, M, Stennicke, H.R, Scott, F.L, Liddington, R.C, Salvesen, G.S. 登録日 2001-09-08 公開日 2001-12-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dimer formation drives the activation of the cell death protease caspase 9. Proc.Natl.Acad.Sci.USA, 98, 2001
3DEK	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 分子名称: Caspase-3, N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide 著者 Wu, J, Du, J, Li, J, Ding, J. 登録日 2008-06-10 公開日 2008-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008

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