1NMQ

Extendend Tethering: In Situ Assembly of Inhibitors

Summary for 1NMQ

Entry DOI	10.2210/pdb1nmq/pdb
Related	1NME 1NMS
Descriptor	Caspase-3, 3-(3-{2-[(5-METHANESULFONYL-THIOPHENE-2-CARBONYL)-AMINO]-ETHYLDISULFANYLMETHYL}- BENZENESULFONYLAMINO)-4-OXO-PENTANOIC ACID (3 entities in total)
Functional Keywords	caspase-3, tethering, small molecule complex, apoptosis, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42574
Total number of polymer chains	2
Total formula weight	58198.48
Authors	Erlanson, D.A.,Lam, J.,Wiesmann, C.,Luong, T.N.,Simmons, R.L.,DeLano, W.,Choong, I.C.,Flanagan, M.,Lee, D.,O'Brian, T. (deposition date: 2003-01-10, release date: 2003-03-11, Last modification date: 2023-08-16)
Primary citation	Erlanson, D.A.,Lam, J.W.,Wiesmann, C.,Luong, T.N.,Simmons, R.L.,DeLano, W.L.,Choong, I.C.,Burdett, M.T.,Flanagan, W.M.,Lee, D.,Gordon, E.M.,O'Brien, T. In situ assembly of enzyme inhibitors using extended tethering. Nat.Biotechnol., 21:308-314, 2003 Cited by PubMed: 12563278 DOI: 10.1038/nbt786 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation