3EDQ

Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO

Summary for 3EDQ

• Entry DOI: 10.2210/pdb3edq/pdb
• Related: 3EDL
• Descriptor: Caspase-3, AC-LDESD-CHO peptide, ... (4 entities in total)
• Functional Keywords: enzyme catalysis, cysteine protease, apoptosis, s-nitrosylation, thiol protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P42574 P42574
• Total number of polymer chains: 6
• Total formula weight: 59933.93

Authors

Fu, G. (deposition date: 2008-09-03, release date: 2008-10-28, Last modification date: 2023-11-15)

• Primary citation: Fu, G.,Chumanevich, A.A.,Agniswamy, J.,Fang, B.,Harrison, R.W.,Weber, I.T.; Structural basis for executioner caspase recognition of P5 position in substrates.; Apoptosis, 13:1291-1302, 2008; PubMed: 18780184; DOI: 10.1007/s10495-008-0259-9

Experimental method

X-RAY DIFFRACTION (1.61 Å)