PDB: 141 件ウェブページステータス検索Chemie searchBIRD

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5FI0	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 分子名称: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.282 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
4XH9	CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1 分子名称: Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA 著者 Garcia, C, Petit, P, Boutin, J.A, Ferry, G, Vuillard, L. 登録日 2015-01-05 公開日 2015-01-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. J. Biol. Chem., 293, 2018
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
2DX1	Crystal structure of RhoGEF protein Asef 分子名称: Rho guanine nucleotide exchange factor 4 著者 Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-22 公開日 2007-01-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism J.Biol.Chem., 282, 2007
1RJ2	Crystal structure of the DH/PH fragment of Dbs without bound GTPase 分子名称: Guanine nucleotide exchange factor DBS [Fragment] 著者 Worthylake, D.K, Rossman, K.L, Sondek, J. 登録日 2003-11-18 公開日 2004-06-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the DH/PH fragment of Dbs without bound GTPase. Structure, 12, 2004
4YON	P-Rex1:Rac1 complex 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Lucato, C.M, Whisstock, J.C, Ellisdon, A.M. 登録日 2015-03-11 公開日 2015-07-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J.Biol.Chem., 290, 2015
2VRW	Critical structural role for the PH and C1 domains of the Vav1 exchange factor 分子名称: PROTO-ONCOGENE VAV, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, ZINC ION 著者 Rapley, J, Tybulewicz, V, Rittinger, K. 登録日 2008-04-16 公開日 2008-06-17 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor. Embo Rep., 9, 2008
3BJI	Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 分子名称: Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION 著者 Chrencik, J.E, Brooun, A, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) 登録日 2007-12-04 公開日 2008-07-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J.Mol.Biol., 380, 2008
6NFA	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity 分子名称: (2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol, Proto-oncogene vav, ZINC ION 著者 Knapp, M.S, Elling, R.A, Ornelas, E. 登録日 2018-12-19 公開日 2019-12-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
4MT7	Crystal structure of collybistin I 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
4MT6	Crystal structure of closed inactive collybistin 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (5.501 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
2DFK	Crystal structure of the CDC42-Collybistin II complex 分子名称: GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ... 著者 Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H. 登録日 2006-03-02 公開日 2006-05-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor. J.Mol.Biol., 359, 2006
2Z0Q	Crystal structure of DH-PH domain of RhoGEF3(Xpln) 分子名称: Rho guanine nucleotide exchange factor 3, SULFATE ION 著者 Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-05-07 公開日 2008-05-13 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F, 68, 2012
3KZ1	Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ... 著者 Chen, Z, Sternweis, P.C, Sprang, S.R. 登録日 2009-12-07 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285, 2010
3KY9	Autoinhibited Vav1 分子名称: Proto-oncogene vav, ZINC ION 著者 Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B. 登録日 2009-12-04 公開日 2010-02-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.731 Å) 主引用文献 Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 Cell(Cambridge,Mass.), 140, 2010
6NEW	Apo structure of the activated truncation of Vav1 分子名称: Proto-oncogene vav, ZINC ION 著者 Knapp, M.S, Elling, R.A, Ornelas, E. 登録日 2018-12-18 公開日 2019-12-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
1DBH	DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 分子名称: PROTEIN (HUMAN SOS 1) 著者 Soisson, S.M, Kuriyan, J. 登録日 1998-12-17 公開日 1998-12-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell(Cambridge,Mass.), 95, 1998
3KSY	Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS) 分子名称: Son of sevenless homolog 1 著者 Gureasko, J, Kuchment, O, Kuriyan, J. 登録日 2009-11-24 公開日 2010-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.178 Å) 主引用文献 Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc.Natl.Acad.Sci.USA, 107, 2010
6NF1	Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity 分子名称: (2S)-3-[(3S)-1-(ethylsulfonyl)piperidin-3-yl]-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}propan-1-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proto-oncogene vav, ... 著者 Knapp, M.S, Elling, R.A, Ornelas, E. 登録日 2018-12-18 公開日 2019-12-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Allosteric Inhibitors of VAV1 Block Guanine Nucleotide Exchange Activity To Be Published
7RX9	Structure of autoinhibited P-Rex1 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Endolysin chimera, SULFATE ION 著者 Ellisdon, A.M, Chang, Y. 登録日 2021-08-22 公開日 2022-08-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
3QBV	Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin 分子名称: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1 著者 Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T. 登録日 2011-01-14 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc.Natl.Acad.Sci.USA, 109, 2012
7SJ4	Human Trio residues 1284-1959 in complex with Rac1 分子名称: Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein 著者 Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. 登録日 2021-10-15 公開日 2022-07-06 最終更新日 2022-08-24 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J.Biol.Chem., 298, 2022
1FOE	CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 分子名称: RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION, T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 著者 Worthylake, D.K, Rossman, K.L, Sondek, J. 登録日 2000-08-27 公開日 2001-01-17 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature, 408, 2000
2NZ8	N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 分子名称: ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein 著者 Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. 登録日 2006-11-22 公開日 2007-04-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation J.Mol.Biol., 368, 2007
3JV3	Structure of SH3E-DH unit of murine intersectin-1L 分子名称: Intersectin-1 著者 Ahmad, K.F. 登録日 2009-09-15 公開日 2010-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. Plos One, 5, 2010

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