5FI0
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1
Summary for 5FI0
Entry DOI | 10.2210/pdb5fi0/pdb |
Related | 5FI1 |
Descriptor | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1, PHOSPHATE ION (3 entities in total) |
Functional Keywords | dbl homology domain, pleckstrin homology domain, beta sandwich, small gtpase, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 259892.12 |
Authors | Cash, J.N.,Tesmer, J.J.G. (deposition date: 2015-12-22, release date: 2016-04-20, Last modification date: 2023-09-27) |
Primary citation | Cash, J.N.,Davis, E.M.,Tesmer, J.J. Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24:730-740, 2016 Cited by PubMed: 27150042DOI: 10.1016/j.str.2016.02.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.282 Å) |
Structure validation
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