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5FI0

Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1

Summary for 5FI0
Entry DOI10.2210/pdb5fi0/pdb
Related5FI1
DescriptorPhosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1, PHOSPHATE ION (3 entities in total)
Functional Keywordsdbl homology domain, pleckstrin homology domain, beta sandwich, small gtpase, protein binding
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight259892.12
Authors
Cash, J.N.,Tesmer, J.J.G. (deposition date: 2015-12-22, release date: 2016-04-20, Last modification date: 2023-09-27)
Primary citationCash, J.N.,Davis, E.M.,Tesmer, J.J.
Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24:730-740, 2016
Cited by
PubMed: 27150042
DOI: 10.1016/j.str.2016.02.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.282 Å)
Structure validation

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