5FI1

Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42

Summary for 5FI1

Entry DOI	10.2210/pdb5fi1/pdb
Related	5D27 5D3V 5D3W 5D3X 5D3Y 5FI0
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Cell division control protein 42 homolog (2 entities in total)
Functional Keywords	dbl homology domain, pleckstrin homology domain, gtpase, rhogef, protein binding, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	64683.53
Authors	Cash, J.N.,Tesmer, J.J.G. (deposition date: 2015-12-22, release date: 2016-04-20, Last modification date: 2023-09-27)
Primary citation	Cash, J.N.,Davis, E.M.,Tesmer, J.J. Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24:730-740, 2016 Cited by PubMed: 27150042 DOI: 10.1016/j.str.2016.02.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.203 Å)

Structure validation