3BJI

Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1

Summary for 3BJI

• Entry DOI: 10.2210/pdb3bji/pdb
• Related: 1F5X 1FOE
• Descriptor: Proto-oncogene vav, Ras-related C3 botulinum toxin substrate 1 precursor, ZINC ION, ... (4 entities in total)
• Functional Keywords: protein-protein interaction, gef/gtpase, atypical cysteine rich domain, guanine-nucleotide releasing factor, metal-binding, phorbol-ester binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, zinc, zinc-finger, adp-ribosylation, alternative splicing, gtp-binding, lipoprotein, membrane, methylation, nucleotide-binding, polymorphism, prenylation, signaling protein, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000
• Total number of polymer chains: 4
• Total formula weight: 128661.33

Authors

Chrencik, J.E.,Brooun, A.,Kuhn, P.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (deposition date: 2007-12-04, release date: 2008-07-15, Last modification date: 2024-03-13)

• Primary citation: Chrencik, J.E.,Brooun, A.,Zhang, H.,Mathews, I.I.,Hura, G.L.,Foster, S.A.,Perry, J.J.,Streiff, M.,Ramage, P.,Widmer, H.,Bokoch, G.M.,Tainer, J.A.,Weckbecker, G.,Kuhn, P.; Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.; J.Mol.Biol., 380:828-843, 2008; PubMed: 18589439; DOI: 10.1016/j.jmb.2008.05.024

Experimental method

X-RAY DIFFRACTION (2.6 Å)