3KSY

Crystal structure of the Histone domain, DH-PH unit, and catalytic unit of the Ras activator Son of Sevenless (SOS)

Summary for 3KSY

Entry DOI	10.2210/pdb3ksy/pdb
Descriptor	Son of sevenless homolog 1 (1 entity in total)
Functional Keywords	ras, sos, ras activator, son of sevenless, disease mutation, guanine-nucleotide releasing factor, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	121967.73
Authors	Gureasko, J.,Kuchment, O.,Kuriyan, J. (deposition date: 2009-11-24, release date: 2010-02-16, Last modification date: 2024-02-21)
Primary citation	Gureasko, J.,Kuchment, O.,Makino, D.L.,Sondermann, H.,Bar-Sagi, D.,Kuriyan, J. Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless. Proc.Natl.Acad.Sci.USA, 107:3430-3435, 2010 Cited by PubMed: 20133692 DOI: 10.1073/pnas.0913915107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.178 Å)

Structure validation