4XH9
CRYSTAL STRUCTURE OF HUMAN RHOA IN COMPLEX WITH DH/PH FRAGMENT OF THE GUANINE NUCLEOTIDE EXCHANGE FACTOR NET1
Summary for 4XH9
Entry DOI | 10.2210/pdb4xh9/pdb |
Descriptor | Neuroepithelial cell-transforming gene 1 protein, Transforming protein RhoA (3 entities in total) |
Functional Keywords | rhoa gtpase, signaling protein, activator, guanine nucleotide exchange factor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 125043.09 |
Authors | Garcia, C.,Petit, P.,Boutin, J.A.,Ferry, G.,Vuillard, L. (deposition date: 2015-01-05, release date: 2015-01-14, Last modification date: 2024-01-10) |
Primary citation | Petit, A.P.,Garcia-Petit, C.,Bueren-Calabuig, J.A.,Vuillard, L.M.,Ferry, G.,Boutin, J.A. A structural study of the complex between neuroepithelial cell transforming gene 1 (Net1) and RhoA reveals a potential anticancer drug hot spot. J. Biol. Chem., 293:9064-9077, 2018 Cited by PubMed: 29695506DOI: 10.1074/jbc.RA117.001123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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