PDB: 413 resultsInfo pagesStatus searchChemie searchBIRD

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4G35	Mcl-1 in complex with a biphenyl cross-linked Noxa peptide. Descriptor: 4,4'-bis(bromomethyl)biphenyl, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked) Authors: Drake, E, Edwardraja, S, Lin, Q, Gulick, A.M. Deposit date: 2012-07-13 Release date: 2012-12-05 Last modified: 2013-06-26 Method: X-RAY DIFFRACTION (2 Å) Cite: Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J.Am.Chem.Soc., 134, 2012
4B4S	Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex Descriptor: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL Authors: Rautureau, G.J.P, Hinds, M.G, Kvansakul, M. Deposit date: 2012-08-01 Release date: 2013-01-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist. Cell Death Dis., 3, 2012
4BD2	Bax domain swapped dimer in complex with BidBH3 Descriptor: APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST Authors: Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. Deposit date: 2012-10-04 Release date: 2013-02-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.206 Å) Cite: Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BD7	Bax domain swapped dimer induced by octylmaltoside Descriptor: APOPTOSIS REGULATOR BAX, CHLORIDE ION, PRASEODYMIUM ION Authors: Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. Deposit date: 2012-10-05 Release date: 2013-02-13 Method: X-RAY DIFFRACTION (2.801 Å) Cite: Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BD8	Bax domain swapped dimer induced by BimBH3 with CHAPS Descriptor: 1,2-ETHANEDIOL, APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION Authors: Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. Deposit date: 2012-10-05 Release date: 2013-02-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BD6	Bax domain swapped dimer in complex with BaxBH3 Descriptor: APOPTOSIS REGULATOR BAX Authors: Czabotar, P.E, Westphal, D, Adams, J.M, Colman, P.M. Deposit date: 2012-10-05 Release date: 2013-02-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.494 Å) Cite: Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4BDU	Bax BH3-in-Groove dimer (GFP) Descriptor: GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX Authors: Czabotar, P.E, Colman, P.M. Deposit date: 2012-10-08 Release date: 2013-02-13 Last modified: 2019-10-23 Method: X-RAY DIFFRACTION (2.998 Å) Cite: Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis. Cell(Cambridge,Mass.), 152, 2013
4HNJ	Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution Descriptor: Bcl-2-binding component 3, Bcl-2-like protein 1 Authors: Fisher, J.C, Yun, M.K, White, S.W. Deposit date: 2012-10-19 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2M03	Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains Descriptor: Bcl-2-like protein 1 Authors: Viacava Follis, A, Royappa, G, Kriwacki, R.W. Deposit date: 2012-10-19 Release date: 2013-01-30 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2M04	Solution structure of BCL-xL in complex with PUMA BH3 peptide Descriptor: Bcl-2-binding component 3, Bcl-2-like protein 1 Authors: Viacava Follis, A, Royappa, G, Kriwacki, R.W. Deposit date: 2012-10-19 Release date: 2013-01-30 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013
2YQ7	Structure of Bcl-xL bound to BimLOCK Descriptor: BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL Authors: Smith, B.J, Czabotar, P.E. Deposit date: 2012-11-06 Release date: 2012-11-28 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.901 Å) Cite: Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
2YQ6	Structure of Bcl-xL bound to BimSAHB Descriptor: BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL Authors: Smith, B.J, Czabotar, P.E. Deposit date: 2012-11-06 Release date: 2012-11-28 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.799 Å) Cite: Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity. Acs Chem.Biol., 8, 2013
4HW2	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Descriptor: 1,2-ETHANEDIOL, 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, ... Authors: Zhao, B. Deposit date: 2012-11-07 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56, 2013
4HW4	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 BH3 peptide Authors: Friberg, A, Zhao, B. Deposit date: 2012-11-07 Release date: 2013-01-09 Last modified: 2013-03-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56, 2013
4HW3	Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design Descriptor: 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 Authors: Zhao, B. Deposit date: 2012-11-07 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56, 2013
4IEH	Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions Descriptor: Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide Authors: Xie, X, Kulathila, R. Deposit date: 2012-12-13 Release date: 2013-07-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. ACS Med Chem Lett, 4, 2013
3ZK6	Crystal structure of Bcl-xL in complex with inhibitor (Compound 2). Descriptor: BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide Authors: Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. Deposit date: 2013-01-22 Release date: 2013-04-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
3ZLN	Crystal structure of BCL-XL in complex with inhibitor (Compound 3) Descriptor: 1,2-ETHANEDIOL, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, BCL-2-LIKE PROTEIN 1, ... Authors: Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. Deposit date: 2013-02-04 Release date: 2013-04-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.288 Å) Cite: Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
3ZLO	Crystal structure of BCL-XL in complex with inhibitor (Compound 6) Descriptor: 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1 Authors: Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. Deposit date: 2013-02-04 Release date: 2013-04-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.601 Å) Cite: Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
3ZLR	Crystal structure of BCL-XL in complex with inhibitor (WEHI-539) Descriptor: 1,2-ETHANEDIOL, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, BCL-2-LIKE PROTEIN 1, ... Authors: Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. Deposit date: 2013-02-04 Release date: 2013-04-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.026 Å) Cite: Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013
2M5B	The NMR structure of the BID-BAK complex Descriptor: Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB Authors: Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R. Deposit date: 2013-02-19 Release date: 2013-04-17 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: BID-induced structural changes in BAK promote apoptosis. Nat.Struct.Mol.Biol., 20, 2013
4K5A	Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W Descriptor: Bcl-2-like protein 2, Designed Ankyrin Repeat Protein 013_D12 Authors: Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. Deposit date: 2013-04-14 Release date: 2014-04-16 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
4K5B	Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W Descriptor: Apoptosis regulator BCL-W, Bcl-2-like protein 2 Authors: Schilling, J, Schoeppe, J, Sauer, E, Plueckthun, A. Deposit date: 2013-04-14 Release date: 2014-04-16 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Co-Crystallization with Conformation-Specific Designed Ankyrin Repeat Proteins Explains the Conformational Flexibility of BCL-W J.Mol.Biol., 426, 2014
4BPJ	Mcl-1 bound to alpha beta Puma BH3 peptide 3 Descriptor: ALPHA BETA BH3-PEPTIDE, CHLORIDE ION, FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG, ... Authors: Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. Deposit date: 2013-05-27 Release date: 2014-04-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins. Chembiochem, 14, 2013
4BPI	Mcl-1 bound to alpha beta Puma BH3 peptide 2 Descriptor: ALPHA BETA BH3PEPTIDE, CADMIUM ION, FUSION PROTEIN CONSISTING OF INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 HOMOLOG Authors: Smith, B.J, Lee, E.F, Checco, J.W, Gellman, S.H, Fairlie, W.D. Deposit date: 2013-05-27 Release date: 2014-04-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.982 Å) Cite: Structure-Guided Rational Design of Alpha/Beta-Peptide Foldamers with High Affinity for Bcl-2 Family Prosurvival Proteins. Chembiochem, 14, 2013

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