2M04

Solution structure of BCL-xL in complex with PUMA BH3 peptide

Summary for 2M04

• Entry DOI: 10.2210/pdb2m04/pdb
• Related: 2M03 4HNJ
• NMR Information: BMRB: 18793
• Descriptor: Bcl-2-like protein 1, Bcl-2-binding component 3 (2 entities in total)
• Functional Keywords: bcl-xl, puma, apoptosis-protein binding complex, apoptosis/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion membrane; Single-pass membrane protein: Q07817; Mitochondrion: Q9BXH1
• Total number of polymer chains: 2
• Total formula weight: 23727.05

Authors

Viacava Follis, A.,Royappa, G.,Kriwacki, R.W. (deposition date: 2012-10-19, release date: 2013-01-30, Last modification date: 2013-03-06)

• Primary citation: Follis, A.V.,Chipuk, J.E.,Fisher, J.C.,Yun, M.K.,Grace, C.R.,Nourse, A.,Baran, K.,Ou, L.,Min, L.,White, S.W.,Green, D.R.,Kriwacki, R.W.; PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.; Nat.Chem.Biol., 9:163-168, 2013; PubMed: 23340338; DOI: 10.1038/nchembio.1166

Experimental method

SOLUTION NMR