Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 10 results
6BF2
DownloadVisualize
BU of 6bf2 by Molmil
Solution structure of a Bcl-xL S62E mutant
Descriptor: Bcl-2-like protein 1
Authors:Viacava Follis, A, Phillips, A, Kriwacki, R.W.
Deposit date:2017-10-25
Release date:2017-11-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.
Nat. Chem. Biol., 14, 2018
7KXO
DownloadVisualize
BU of 7kxo by Molmil
BTK1 SOAKED WITH COMPOUND 24
Descriptor: 3-tert-butyl-N-[(1R)-6-{2-[5-methyl-1-(oxan-4-yl)-1H-pyrazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Isoform BTK-C of Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXN
DownloadVisualize
BU of 7kxn by Molmil
BTK1 SOAKED WITH COMPOUND 26
Descriptor: 3-tert-butyl-N-[(1S)-6-{2-[5-methyl-1-(propan-2-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Isoform BTK-C of Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXQ
DownloadVisualize
BU of 7kxq by Molmil
BTK1 SOAKED WITH COMPOUND 30
Descriptor: 3-tert-butyl-N-[(5R)-2-{2-[3,5-dimethyl-1-(propan-2-yl)-1H-pyrazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl}-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Isoform BTK-C of Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
7KXP
DownloadVisualize
BU of 7kxp by Molmil
BTK1 SOAKED WITH COMPOUND 25
Descriptor: 3-tert-butyl-N-[(1S)-6-{2-[3-methyl-1-(oxan-4-yl)-1H-pyrazol-4-yl]-1H-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK
Authors:Viacava Follis, A.
Deposit date:2020-12-04
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg.Med.Chem., 40, 2021
2M03
DownloadVisualize
BU of 2m03 by Molmil
Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains
Descriptor: Bcl-2-like protein 1
Authors:Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:2012-10-19
Release date:2013-01-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
2M04
DownloadVisualize
BU of 2m04 by Molmil
Solution structure of BCL-xL in complex with PUMA BH3 peptide
Descriptor: Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:2012-10-19
Release date:2013-01-30
Last modified:2013-03-06
Method:SOLUTION NMR
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
2MEJ
DownloadVisualize
BU of 2mej by Molmil
Solution Structure of the Complex Between BCL-xL and the p53 Core Domain determined with PRE restraints
Descriptor: Bcl-2-like protein 1, Cellular tumor antigen p53, ZINC ION
Authors:Viacava Follis, A, Grace, C.R, Kriwacki, R.W.
Deposit date:2013-09-25
Release date:2014-04-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2ME9
DownloadVisualize
BU of 2me9 by Molmil
Solution structure of BCL-xL containing the alpha1-alpha2 disordered loop determined with selective isotope labelling of I,L,V sidechains
Descriptor: Bcl-2-like protein 1
Authors:Viacava Follis, A, Grace, C.R, Kriwacki, R.W.
Deposit date:2013-09-25
Release date:2014-04-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014
2ME8
DownloadVisualize
BU of 2me8 by Molmil
Solution Structure of BCL-xL in its p53-bound conformation determined with selective isotope labelling of I,L,V sidechains
Descriptor: Bcl-2-like protein 1
Authors:Viacava Follis, A, Grace, C.R, Kriwacki, R.W.
Deposit date:2013-09-25
Release date:2014-04-30
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The DNA-binding domain mediates both nuclear and cytosolic functions of p53.
Nat.Struct.Mol.Biol., 21, 2014

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon