4HNJ

Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution

Summary for 4HNJ

Entry DOI	10.2210/pdb4hnj/pdb
Related	2M03 2M04
Descriptor	Bcl-2-like protein 1, Bcl-2-binding component 3 (3 entities in total)
Functional Keywords	bcl2-family, domain-swapped dimer, apoptosis regulation, bcl-xl, puma, apoptosis-protein binding complex, apoptosis/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 Mitochondrion : Q9BXH1
Total number of polymer chains	3
Total formula weight	50393.22
Authors	Fisher, J.C.,Yun, M.K.,White, S.W. (deposition date: 2012-10-19, release date: 2013-01-23, Last modification date: 2023-09-20)
Primary citation	Follis, A.V.,Chipuk, J.E.,Fisher, J.C.,Yun, M.K.,Grace, C.R.,Nourse, A.,Baran, K.,Ou, L.,Min, L.,White, S.W.,Green, D.R.,Kriwacki, R.W. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9:163-168, 2013 Cited by PubMed: 23340338 DOI: 10.1038/nchembio.1166 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation