4B4S

Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex

Summary for 4B4S

• Entry DOI: 10.2210/pdb4b4s/pdb
• Related: 2V6Q 2VM6 2WH6
• Descriptor: BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL, ... (4 entities in total)
• Functional Keywords: apoptosis
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Mitochondrion: Q9HD36; Endomembrane system; Peripheral membrane protein (By similarity). Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521
• Total number of polymer chains: 2
• Total formula weight: 23112.09

Authors

Rautureau, G.J.P.,Hinds, M.G.,Kvansakul, M. (deposition date: 2012-08-01, release date: 2013-01-16)

• Primary citation: Rautureau, G.J.P.,Yabal, M.,Yang, H.,Huang, D.C.S.,Kvansakul, M.,Hinds, M.G.; The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.; Cell Death Dis., 3:E443-, 2012; PubMed: 23235460; DOI: 10.1038/CDDIS.2012.178

Experimental method

X-RAY DIFFRACTION (1.9 Å)