4HW3
Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design
Summary for 4HW3
Entry DOI | 10.2210/pdb4hw3/pdb |
Related | 4HW2 4HW4 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-benzothiophene-2-carboxylic acid (3 entities in total) |
Functional Keywords | regulation of apoptosis, maintenance of viability, apoptosis, apoptosis-inhibitor complex, apoptosis/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass membrane protein (Potential): Q07820 |
Total number of polymer chains | 12 |
Total formula weight | 214425.44 |
Authors | Zhao, B. (deposition date: 2012-11-07, release date: 2013-01-09, Last modification date: 2024-02-28) |
Primary citation | Friberg, A.,Vigil, D.,Zhao, B.,Daniels, R.N.,Burke, J.P.,Garcia-Barrantes, P.M.,Camper, D.,Chauder, B.A.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J.Med.Chem., 56:15-30, 2013 Cited by PubMed: 23244564DOI: 10.1021/jm301448p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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