3ZK6

Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).

Summary for 3ZK6

Entry DOI	10.2210/pdb3zk6/pdb
Related	3ZLN 3ZLO 3ZLR
Descriptor	BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide (3 entities in total)
Functional Keywords	apoptosis, inhibitor, bcl-2 family
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion membrane; Single-pass membrane protein: Q07817
Total number of polymer chains	2
Total formula weight	42715.56
Authors	Czabotar, P.E.,Lessene, G.L.,Smith, B.J.,Colman, P.M. (deposition date: 2013-01-22, release date: 2013-04-24, Last modification date: 2023-12-20)
Primary citation	Lessene, G.L.,Czabotar, P.E.,Sleebs, B.E.,Zobel, K.,Lowes, K.L.,Adams, J.M.,Baell, J.B.,Colman, P.M.,Deshayes, K.,Fairbrother, W.J.,Flygare, J.A.,Gibbons, P.,Kersten, W.J.A.,Kulasegaram, S.,Moss, R.M.,Parisot, J.P.,Smith, B.J.,Street, I.P.,Yang, H.,Huang, D.C.S.,Watson, K.G. Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9:390-, 2013 Cited by PubMed: 23603658 DOI: 10.1038/NCHEMBIO.1246 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation