PDB: 593 件ウェブページステータス検索Chemie searchBIRD

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4QSY	SHP2 SH2 domain in complex with GAB1 peptide 分子名称: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11 著者 Gogl, G, Remenyi, A. 登録日 2014-07-06 公開日 2015-07-08 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling To be Published
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain 分子名称: Cytoplasmic protein NCK2 著者 Ran, X, Song, J. 登録日 2005-03-14 公開日 2005-03-29 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... 著者 Clements, J.H. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
4K44	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 著者 Hajicek, N, Sondek, J. 登録日 2013-04-11 公開日 2013-06-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
4K45	Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide 著者 Sondek, J, Hajicek, N. 登録日 2013-04-11 公開日 2013-06-26 最終更新日 2014-01-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52, 2013
8X2P	The Crystal Structure of LCK from Biortus. 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, TETRAETHYLENE GLYCOL, ... 著者 Wang, F, Cheng, W, Lv, Z, Meng, Q, Lu, Y. 登録日 2023-11-10 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The Crystal Structure of LCK from Biortus. To Be Published
3PQZ	Grb7 SH2 with peptide 分子名称: Growth factor receptor-bound protein 7, cyclic peptide 著者 Wilce, J.A. 登録日 2010-11-29 公開日 2011-07-20 最終更新日 2011-09-21 実験手法 X-RAY DIFFRACTION (2.413 Å) 主引用文献 Structural basis of binding by cyclic nonphosphorylated Peptide antagonists of grb7 implicated in breast cancer progression J.Mol.Biol., 412, 2011
3PSJ	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Se-Spt6 (1247-1451) 分子名称: SULFATE ION, Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3S8N	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... 著者 Clements, J.H, Stephen, F.M. 登録日 2011-05-29 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S9K	Crystal structure of the Itk SH2 domain. 分子名称: CITRIC ACID, Tyrosine-protein kinase ITK/TSK 著者 Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. 登録日 2011-06-01 公開日 2012-02-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.354 Å) 主引用文献 Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
5GJI	PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... 著者 Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. 登録日 2016-06-30 公開日 2016-12-14 最終更新日 2017-05-10 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
5GJH	Gads SH2 domain/CD28-derived peptide complex 分子名称: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28 著者 Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. 登録日 2016-06-30 公開日 2016-12-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area 分子名称: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... 著者 Clements, J.H, Stephen, F.M. 登録日 2011-05-29 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8O	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ... 著者 Clements, J.H, Stephen, F.M. 登録日 2011-05-29 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
5EEQ	Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION 著者 Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
5EEL	Grb7 SH2 with bicyclic peptide inhibitor 分子名称: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ... 著者 Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A. 登録日 2015-10-23 公開日 2016-06-15 最終更新日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Sci Rep, 6, 2016
3PSK	Crystal Structure of the Spt6 Tandem SH2 Domain from Saccharomyces cerevisiae, Form Native Spt6 (1247-1451) 分子名称: SULFATE ION, Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN 著者 Clements, J.H, Martin, S.F. 登録日 2010-09-16 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3T04	Crystal structure of monobody 7c12/abl1 sh2 domain complex 分子名称: GLYCEROL, MONOBODY 7C12, SULFATE ION, ... 著者 Wojcik, J.B, Wyrzucki, A.M, Koide, S. 登録日 2011-07-19 公開日 2011-11-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
3WA4	Grb2 SH2 domain/CD28-derived peptide complex 分子名称: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... 著者 Higo, K, Oda, M, Ito, N. 登録日 2013-04-23 公開日 2014-02-26 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex 分子名称: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 著者 Wojcik, J.B, Koide, A, Koide, S. 登録日 2011-12-06 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
3US4	Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution 分子名称: Megakaryocyte-associated tyrosine-protein kinase, SULFATE ION 著者 Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) 登録日 2011-11-22 公開日 2011-12-28 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution To be published
1SPS	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS 分子名称: PEPTIDE YEEI, SRC SH2 DOMAIN 著者 Waksman, G, Kuriyan, J. 登録日 1993-03-05 公開日 1994-05-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1SKJ	COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX 分子名称: 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID, PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN 著者 Holland, D.R, Rubin, J.R. 登録日 1997-09-18 公開日 1998-02-25 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40, 1997

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