1SKJ
COCRYSTAL STRUCTURE OF UREA-SUBSTITUTED PHOSPHOPEPTIDE COMPLEX
Summary for 1SKJ
Entry DOI | 10.2210/pdb1skj/pdb |
Descriptor | PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN, 4-[3-CARBOXYMETHYL-3-(4-PHOSPHONOOXY-BENZYL)-UREIDO]-4-[(3-CYCLOHEXYL-PROPYL)-METHYL-CARBAMOYL]BUTYRIC ACID (3 entities in total) |
Functional Keywords | tyrosine-protein kinase, v-src sh2 domain, phosphotyrosine recognition domain, pp60 src sh2 domain, peptidomimetic, ureido |
Biological source | Rous sarcoma virus |
Total number of polymer chains | 1 |
Total formula weight | 13479.07 |
Authors | Holland, D.R.,Rubin, J.R. (deposition date: 1997-09-18, release date: 1998-02-25, Last modification date: 2024-05-22) |
Primary citation | Plummer, M.S.,Holland, D.R.,Shahripour, A.,Lunney, E.A.,Fergus, J.H.,Marks, J.S.,McConnell, P.,Mueller, W.T.,Sawyer, T.K. Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. J.Med.Chem., 40:3719-3725, 1997 Cited by PubMed: 9371236DOI: 10.1021/jm970402q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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