PDB: 342 件ウェブページステータス検索Chemie searchBIRD

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1ICE	STRUCTURE AND MECHANISM OF INTERLEUKIN-1BETA CONVERTING ENZYME 分子名称: INTERLEUKIN-1 BETA CONVERTING ENZYME, TETRAPEPTIDE ALDEHYDE 著者 Wilson, K.P, Griffith, J.P, Kim, E.E, Navia, M.A. 登録日 1994-09-29 公開日 1995-07-28 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and mechanism of interleukin-1 beta converting enzyme. Nature, 370, 1994
8F9B	Compound 19 bound to procaspase-6 分子名称: 5-fluoro-2-({[(3M)-3-(1,2-thiazol-3-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6 著者 Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R. 登録日 2022-11-23 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published
3EDR	The crystal structure of caspase-7 in complex with Acetyl-LDESD-CHO 分子名称: Caspase-7, Inhibitor Ac-ldesd-cho peptide 著者 Agniswamy, J. 登録日 2008-09-03 公開日 2008-10-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008
3EDQ	Crystal structure of Caspase-3 with inhibitor AC-LDESD-CHO 分子名称: AC-LDESD-CHO peptide, Caspase-3 著者 Fu, G. 登録日 2008-09-03 公開日 2008-10-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis, 13, 2008
8FBV	Compound 7 bound to procaspase-6 分子名称: 5-fluoro-2-({[(3M)-3-(1H-imidazol-2-yl)pyridin-2-yl]amino}methyl)phenol, Procaspase-6 著者 Fan, P, Zhao, Y, Renslo, A.R, Arkin, M.R. 登録日 2022-11-30 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 A Comprehensive Empirical-Computational Study of Diverse Heteroarene Stacking Interactions Under Physiological Conditions To Be Published
1K88	Crystal structure of procaspase-7 分子名称: procaspase-7 著者 Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. 登録日 2001-10-23 公開日 2001-11-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001
3D6M	Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3D6F	Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published
1K86	Crystal structure of caspase-7 分子名称: caspase-7 著者 Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. 登録日 2001-10-23 公開日 2001-11-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001
3D6H	Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK) 分子名称: Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide 著者 Rosen-Wolff, A, Roesler, J, Romanowski, M.J. 登録日 2008-05-19 公開日 2010-03-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008
3DEJ	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 分子名称: (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 著者 Wu, J, Du, J, Li, J, Ding, J. 登録日 2008-06-10 公開日 2008-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
1IBC	CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME 分子名称: INTERLEUKIN-1BETA CONVERTING ENZYME, PEPTIDE ACE-TRP-GLU-HIS-ASA 著者 Becker, J.W, Rotonda, J. 登録日 1997-02-12 公開日 1998-02-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem.Biol., 4, 1997
3DEK	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 分子名称: Caspase-3, N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide 著者 Wu, J, Du, J, Li, J, Ding, J. 登録日 2008-06-10 公開日 2008-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
1JXQ	Structure of cleaved, CARD domain deleted Caspase-9 分子名称: Caspase-9, benzoxycarbonyl-Val-Ala-Asp-fluoromethyl ketone Inhibitor 著者 Renatus, M, Stennicke, H.R, Scott, F.L, Liddington, R.C, Salvesen, G.S. 登録日 2001-09-08 公開日 2001-12-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dimer formation drives the activation of the cell death protease caspase 9. Proc.Natl.Acad.Sci.USA, 98, 2001
3E4C	Procaspase-1 zymogen domain crystal structure 分子名称: Caspase-1, MAGNESIUM ION 著者 Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M. 登録日 2008-08-11 公開日 2008-12-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J.Biol.Chem., 284, 2009
3DEI	Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors 分子名称: (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate, Caspase-3 著者 Wu, J, Du, J, Li, J, Ding, J. 登録日 2008-06-10 公開日 2008-09-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem., 283, 2008
4DCO	Crystal Structure of caspase 3, L168Y mutant 分子名称: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Chung, S.J, Kang, H.J, Kim, S.J. 登録日 2012-01-18 公開日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4DCJ	Crystal structure of caspase 3, L168D mutant 分子名称: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Chung, S.J, Kang, H.J, Kim, S.J. 登録日 2012-01-17 公開日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4EHA	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.696 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHH	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4DCP	Crystal Structure of caspase 3, L168F mutant 分子名称: Caspase Inhibitor AC-DEVD-CHO, Caspase-3 subunit p12, Caspase-3 subunit p17 著者 Chung, S.J, Kang, H.J, Kim, S.J. 登録日 2012-01-18 公開日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspases 3 and 7 Biosci.Rep., 32, 2012
4EHL	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHD	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.581 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHN	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHK	Allosteric Modulation of Caspase-3 through Mutagenesis 分子名称: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 著者 Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. 登録日 2012-04-02 公開日 2012-06-06 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.668 Å) 主引用文献 Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012

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