3E4C

Procaspase-1 zymogen domain crystal structure

Summary for 3E4C

Entry DOI	10.2210/pdb3e4c/pdb
Related	1RWX
Descriptor	Caspase-1, MAGNESIUM ION (3 entities in total)
Functional Keywords	zymogen, caspase-1, inflammasome, ice, caspase, il-1b, procaspase-1, procaspase, innate immunity, apoptosis, hydrolase, protease, thiol protease
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	67619.11
Authors	Elliott, J.M.,Rouge, L.,Wiesmann, C.,Scheer, J.M. (deposition date: 2008-08-11, release date: 2008-12-30, Last modification date: 2023-08-30)
Primary citation	Elliott, J.M.,Rouge, L.,Wiesmann, C.,Scheer, J.M. Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation J.Biol.Chem., 284:6546-6553, 2009 Cited by PubMed: 19117953 DOI: 10.1074/jbc.M806121200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation