1RWX
Crystal structure of human caspase-1 in complex with 4-oxo-3-{6-[4-(quinoxalin-2-yloxy)-benzoylamino]-2-thiophen-2-yl-hexanoylamino}-butyric acid
Summary for 1RWX
Entry DOI | 10.2210/pdb1rwx/pdb |
Related | 1bmq 1ibc 1ice 1rwk 1rwm 1rwn 1rwo 1rwp 1rwv 1rww |
Descriptor | Interleukin-1 beta convertase, 4-OXO-3-{6-[4-(QUINOXALIN-2-YLOXY)-BENZOYLAMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-BUTYRIC ACID, ... (4 entities in total) |
Functional Keywords | protein-small molecule inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P29466 P29466 |
Total number of polymer chains | 2 |
Total formula weight | 30689.21 |
Authors | Romanowski, M.J.,Fahr, B.T.,O'Brien, T. (deposition date: 2003-12-17, release date: 2004-12-28, Last modification date: 2023-08-23) |
Primary citation | Fahr, B.T.,O'Brien, T.,Pham, P.,Waal, N.D.,Baskaran, S.,Raimundo, B.C.,Lam, J.W.,Sopko, M.M.,Purkey, H.E.,Romanowski, M.J. Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorg.Med.Chem.Lett., 16:559-562, 2006 Cited by PubMed: 16274992DOI: 10.1016/j.bmcl.2005.10.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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