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4EHK

Allosteric Modulation of Caspase-3 through Mutagenesis

Summary for 4EHK
Entry DOI10.2210/pdb4ehk/pdb
Related4EHA 4EHD 4EHF 4EHH 4EHL 4EHN
Related PRD IDPRD_000238
DescriptorCaspase-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR (3 entities in total)
Functional Keywordscaspase, apoptosis, allosteric inhibition, protein ensembles, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P42574
Total number of polymer chains4
Total formula weight64137.63
Authors
Walters, J.,Schipper, J.L.,Swartz, P.D.,Mattos, C.,Clark, A.C. (deposition date: 2012-04-02, release date: 2012-06-06, Last modification date: 2017-11-15)
Primary citationWalters, J.,Schipper, J.L.,Swartz, P.,Mattos, C.,Clark, A.C.
Allosteric modulation of caspase 3 through mutagenesis.
Biosci.Rep., 32:401-411, 2012
Cited by
PubMed: 22607239
DOI: 10.1042/BSR20120037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.668 Å)
Structure validation

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