4EHA
Allosteric Modulation of Caspase-3 through Mutagenesis
Summary for 4EHA
| Entry DOI | 10.2210/pdb4eha/pdb |
| Related | 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN |
| Related PRD ID | PRD_000238 |
| Descriptor | Caspase-3, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR (3 entities in total) |
| Functional Keywords | caspase, apoptosis, allosteric inhibition, protein ensembles, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P42574 |
| Total number of polymer chains | 4 |
| Total formula weight | 64451.80 |
| Authors | Walters, J.,Schipper, J.L.,Swartz, P.D.,Mattos, C.,Clark, A.C. (deposition date: 2012-04-02, release date: 2012-06-06, Last modification date: 2017-11-15) |
| Primary citation | Walters, J.,Schipper, J.L.,Swartz, P.,Mattos, C.,Clark, A.C. Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32:401-411, 2012 Cited by PubMed: 22607239DOI: 10.1042/BSR20120037 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.696 Å) |
Structure validation
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