PDB: 457 件ウェブページステータス検索Chemie searchBIRD

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1EWO	THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204 分子名称: CRUZAIN, N-[N'-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC ACID PHENYL ESTER 著者 Brinen, L.S, Gillmor, S.A, Fletterick, R.J. 登録日 2000-04-26 公開日 2003-06-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Cruzain bound to WRR-204 To be Published
1F29	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I) 分子名称: 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, CRUZAIN 著者 Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. 登録日 2000-05-23 公開日 2000-07-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2A	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II) 分子名称: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE, CRUZAIN 著者 Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. 登録日 2000-05-23 公開日 2000-07-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2B	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III) 分子名称: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID 4-NITRO-PHENYL ESTER, CRUZAIN 著者 Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. 登録日 2000-05-23 公開日 2000-07-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2C	CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV) 分子名称: 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, CRUZAIN 著者 Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. 登録日 2000-05-23 公開日 2000-07-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
2F7D	A mutant rabbit cathepsin K with a nitrile inhibitor 分子名称: (1R,2R)-N-(2-AMINOETHYL)-2-{[(4-METHOXYPHENYL)SULFONYL]METHYL}CYCLOHEXANECARBOXAMIDE, Cathepsin K 著者 Somoza, J.R. 登録日 2005-11-30 公開日 2006-03-07 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J.Med.Chem., 49, 2006
2F1G	Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide 分子名称: Cathepsin S, GLYCEROL, N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE 著者 Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K. 登録日 2005-11-14 公開日 2006-04-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3. Bioorg.Med.Chem.Lett., 16, 2006
1MS6	Dipeptide Nitrile Inhibitor Bound to Cathepsin S. 分子名称: Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE 著者 Ward, Y.D, Thomson, D.S, Frye, L.L, Cywin, C.L, Morwick, T, Emmanuel, M.J, Zindell, R, McNeil, D, Bekkali, Y, Giradot, M, Hrapchak, M, DeTuri, M, Crane, K, White, D, Pav, S, Wang, Y, Hao, M.H, Grygon, C.A, Labadia, M.E, Freeman, D.M, Davidson, W, Hopkins, J.L, Brown, M.L, Spero, D.M. 登録日 2002-09-19 公開日 2003-04-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors J.Med.Chem., 45, 2002
1NLJ	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR 分子名称: BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE, CATHEPSIN K 著者 Smith, W.W, Janson, C.A, Zhao, B. 登録日 2003-01-07 公開日 2003-01-14 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Azepanone-Based Inhibitors of Human and Rat Cathepsin K J.Med.Chem., 44, 2001
1NQC	Crystal structures of Cathepsin S inhibitor complexes 分子名称: Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE 著者 Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Menard, R, Cygler, M, Rath, V.L. 登録日 2003-01-21 公開日 2003-04-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1NL6	Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor 分子名称: 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE, Cathepsin K 著者 Smith, W.W, Janson, C.A, Zhao, B. 登録日 2003-01-06 公開日 2003-01-14 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Azepanone-based inhibitors of human and rat cathepsin K J.Med.Chem., 44, 2001
1ME3	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II) 分子名称: Cruzipain, [1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER 著者 Brinen, L.S, Huang, L, Ellman, J.A. 登録日 2002-08-07 公開日 2002-12-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1ME4	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I) 分子名称: CRUZIPAIN, [1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 著者 Brinen, L.S, Huang, L, Ellman, J.A. 登録日 2002-08-07 公開日 2002-12-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1NPZ	Crystal structures of Cathepsin S inhibitor complexes 分子名称: Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide 著者 Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Seddon, A.P, Menard, R, Cygler, M, Rath, V.L. 登録日 2003-01-20 公開日 2003-04-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1MEM	Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor 分子名称: Cathepsin K, N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide 著者 Mcgrath, M.E. 登録日 1997-01-08 公開日 1998-01-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat.Struct.Biol., 4, 1997
1O0E	1.9 Angstrom Crystal Structure of a plant cysteine protease Ervatamin C 分子名称: Ervatamin C, THIOSULFATE 著者 Thakurta, P.G, Chakrabarti, C, Biswas, S, Dattagupta, J.K. 登録日 2003-02-21 公開日 2004-03-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis of the Unusual Stability and Substrate Specificity of Ervatamin C, a Plant Cysteine Protease from Ervatamia coronaria Biochemistry, 43, 2004
1PIP	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS 分子名称: Papain, SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE 著者 Yamamoto, A, Tomoo, K, Doi, M, Ohishi, H, Inoue, M, Ishida, T, Yamamoto, D, Tsuboi, S, Okamoto, H, Okada, Y. 登録日 1992-10-03 公開日 1993-10-31 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors. Biochemistry, 31, 1992
1PE6	REFINED X-RAY STRUCTURE OF PAPAIN(DOT)E-64-C COMPLEX AT 2.1-ANGSTROMS RESOLUTION 分子名称: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN 著者 Yamamoto, D, Matsumoto, K, Ohishi, H, Ishida, T, Inoue, M, Kitamura, K, Mizuno, H. 登録日 1991-05-14 公開日 1993-04-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. J.Biol.Chem., 266, 1991
1PPO	DETERMINATION OF THE STRUCTURE OF PAPAYA PROTEASE OMEGA 分子名称: MERCURY (II) ION, PROTEASE OMEGA 著者 Pickersgill, R.W, Rizkallah, P.J, Harris, G.W, Goodenough, P.W. 登録日 1991-07-12 公開日 1993-10-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Determination of the Structure of Papaya Protease Omega Acta Crystallogr.,Sect.B, 47, 1991
1PAD	Binding of chloromethyl ketone substrate analogues to crystalline papain 分子名称: ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR, PAPAIN 著者 Drenth, J, Kalk, K.H, Swen, H.M. 登録日 1976-11-01 公開日 1977-04-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding of chloromethyl ketone substrate analogues to crystalline papain. Biochemistry, 15, 1976
1MEG	CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64 分子名称: CARICAIN, ETHANOL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE 著者 Katerelos, N.A. 登録日 1996-05-04 公開日 1997-01-11 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a caricain D158E mutant in complex with E-64. FEBS Lett., 392, 1996
1POP	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX 分子名称: LEUPEPTIN, METHANOL, PAPAIN 著者 Schroder, E, Crawford, C. 登録日 1993-06-24 公開日 1993-10-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett., 315, 1993
1PPN	STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION 分子名称: METHANOL, PAPAIN, UNKNOWN LIGAND 著者 Pickersgill, R.W, Harris, G.W, Garman, E. 登録日 1991-10-25 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of Monoclinic Papain at 1.60 Angstroms Resolution Acta Crystallogr.,Sect.B, 48, 1992
1PPP	CRYSTAL STRUCTURE OF PAPAIN-E64-C COMPLEX. BINDING DIVERSITY OF E64-C TO PAPAIN S2 AND S3 SUBSITES 分子名称: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN 著者 Ishida, T. 登録日 1993-03-17 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites. Biochem.J., 287, 1992
1PPD	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS 分子名称: 2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL 著者 Jansonius, J.N. 登録日 1984-11-06 公開日 1985-01-02 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984

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