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1NL6

Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor

Summary for 1NL6
Entry DOI10.2210/pdb1nl6/pdb
Related1ATK 1AU0 1AU2 1AU3 1AU4
DescriptorCathepsin K, 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE (2 entities in total)
Functional Keywordshydrolase, sulfhydryl proteinase
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P43235
Total number of polymer chains2
Total formula weight48466.62
Authors
Smith, W.W.,Janson, C.A.,Zhao, B. (deposition date: 2003-01-06, release date: 2003-01-14, Last modification date: 2023-08-16)
Primary citationMarquis, R.W.,Ru, Y.,LoCastro, S.M.,Zeng, J.,Yamashita, D.S.,Oh, H.J.,Erhard, K.F.,Davis, L.D.,Tomaszek, T.A.,Tew, D.,Salyers, K.,Proksch, J.,Ward, K.,Smith, B.,Levy, M.,Cummings, M.D.,Haltiwanger, R.C.,Trescher, G.,Wang, B.,Hemling, M.E.,Quinn, C.J.,Cheng, H.-Y.,Lin, F.,Smith, W.W.,Janson, C.A.,Zhao, B.,McQueney, M.S.,D'Alessio, K.,Lee, C.P.,Marzulli, A.,A Dodds, R.,Blake, S.,Hwang, S.M.,James, I.E.,Gress, C.J.,Bradley, B.R.,Lark, M.W.,Gowen, M.,Veber, D.F.
Azepanone-based inhibitors of human and rat cathepsin K
J.Med.Chem., 44:1380-1395, 2001
Cited by
PubMed: 11311061
DOI: 10.1021/jm000481x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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