1NPZ

Crystal structures of Cathepsin S inhibitor complexes

Summary for 1NPZ

Entry DOI	10.2210/pdb1npz/pdb
Related	1NQC
Descriptor	Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide (3 entities in total)
Functional Keywords	antigen presentation, binding specificity, cysteine proteases, inhibitor complexes, structure-based design, structural plasticity, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P25774
Total number of polymer chains	2
Total formula weight	49101.31
Authors	Pauly, T.A.,Sulea, T.,Ammirati, M.,Sivaraman, J.,Danley, D.E.,Griffor, M.C.,Kamath, A.V.,Wang, I.K.,Laird, E.R.,Seddon, A.P.,Menard, R.,Cygler, M.,Rath, V.L. (deposition date: 2003-01-20, release date: 2003-04-15, Last modification date: 2023-08-16)
Primary citation	Pauly, T.A.,Sulea, T.,Ammirati, M.,Sivaraman, J.,Danley, D.E.,Griffor, M.C.,Kamath, A.V.,Wang, I.K.,Laird, E.R.,Seddon, A.P.,Menard, R.,Cygler, M.,Rath, V.L. Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42:3203-3213, 2003 Cited by PubMed: 12641451 DOI: 10.1021/bi027308i PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation