1F2A

CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II)

Summary for 1F2A

Entry DOI	10.2210/pdb1f2a/pdb
Related	1AIM 1EWL 1EWM 1EWO 1EWP 1F29 1F2B 1F2C 2AIM
Descriptor	CRUZAIN, 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE (3 entities in total)
Functional Keywords	cysteine protease, covalent inhibitor, vinyl sulfone derived, p1' pocket, hydrolase
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	23313.89
Authors	Brinen, L.S.,Hansell, E.,Roush, W.R.,McKerrow, J.H.,Fletterick, R.J. (deposition date: 2000-05-23, release date: 2000-07-26, Last modification date: 2011-07-13)
Primary citation	Brinen, L.S.,Hansell, E.,Cheng, J.,Roush, W.R.,McKerrow, J.H.,Fletterick, R.J. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8:831-840, 2000 Cited by PubMed: 10997902 DOI: 10.1016/S0969-2126(00)00173-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation