1ME3
High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)
Summary for 1ME3
| Entry DOI | 10.2210/pdb1me3/pdb |
| Related | 1f29 1f2a 1f2b 1f2c 1me4 |
| Descriptor | Cruzipain, [1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER (3 entities in total) |
| Functional Keywords | cysteine protease, non-covalent inhibitor, hydrolase |
| Biological source | Trypanosoma cruzi |
| Total number of polymer chains | 1 |
| Total formula weight | 23190.67 |
| Authors | Brinen, L.S.,Huang, L.,Ellman, J.A. (deposition date: 2002-08-07, release date: 2002-12-18, Last modification date: 2017-10-11) |
| Primary citation | Huang, L.,Brinen, L.S.,Ellman, J.A. Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11:21-29, 2003 Cited by PubMed: 12467703DOI: 10.1016/S0968-0896(02)00427-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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