2F7D

A mutant rabbit cathepsin K with a nitrile inhibitor

Summary for 2F7D

Entry DOI	10.2210/pdb2f7d/pdb
Descriptor	Cathepsin K, (1R,2R)-N-(2-AMINOETHYL)-2-{[(4-METHOXYPHENYL)SULFONYL]METHYL}CYCLOHEXANECARBOXAMIDE (3 entities in total)
Functional Keywords	papain cysteine protease, hydrolase
Biological source	Oryctolagus cuniculus (rabbit)
Cellular location	Lysosome : P43236
Total number of polymer chains	1
Total formula weight	23908.96
Authors	Somoza, J.R. (deposition date: 2005-11-30, release date: 2006-03-07, Last modification date: 2021-10-20)
Primary citation	Crane, S.N.,Black, W.C.,Palmer, J.T.,Davis, D.E.,Setti, E.,Robichaud, J.,Paquet, J.,Oballa, R.M.,Bayly, C.I.,McKay, D.J.,Somoza, J.R.,Chauret, N.,Seto, C.,Scheigetz, J.,Wesolowski, G.,Masse, F.,Desmarais, S.,Ouellet, M. Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J.Med.Chem., 49:1066-1079, 2006 Cited by PubMed: 16451072 DOI: 10.1021/jm051059p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation