2F7D
A mutant rabbit cathepsin K with a nitrile inhibitor
Summary for 2F7D
Entry DOI | 10.2210/pdb2f7d/pdb |
Descriptor | Cathepsin K, (1R,2R)-N-(2-AMINOETHYL)-2-{[(4-METHOXYPHENYL)SULFONYL]METHYL}CYCLOHEXANECARBOXAMIDE (3 entities in total) |
Functional Keywords | papain cysteine protease, hydrolase |
Biological source | Oryctolagus cuniculus (rabbit) |
Cellular location | Lysosome : P43236 |
Total number of polymer chains | 1 |
Total formula weight | 23908.96 |
Authors | Somoza, J.R. (deposition date: 2005-11-30, release date: 2006-03-07, Last modification date: 2021-10-20) |
Primary citation | Crane, S.N.,Black, W.C.,Palmer, J.T.,Davis, D.E.,Setti, E.,Robichaud, J.,Paquet, J.,Oballa, R.M.,Bayly, C.I.,McKay, D.J.,Somoza, J.R.,Chauret, N.,Seto, C.,Scheigetz, J.,Wesolowski, G.,Masse, F.,Desmarais, S.,Ouellet, M. Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J.Med.Chem., 49:1066-1079, 2006 Cited by PubMed: 16451072DOI: 10.1021/jm051059p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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