1MS6
Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
Summary for 1MS6
Entry DOI | 10.2210/pdb1ms6/pdb |
Descriptor | Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE (2 entities in total) |
Functional Keywords | hydrolase, cathepsin, protease |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P25774 |
Total number of polymer chains | 1 |
Total formula weight | 25100.16 |
Authors | Ward, Y.D.,Thomson, D.S.,Frye, L.L.,Cywin, C.L.,Morwick, T.,Emmanuel, M.J.,Zindell, R.,McNeil, D.,Bekkali, Y.,Giradot, M.,Hrapchak, M.,DeTuri, M.,Crane, K.,White, D.,Pav, S.,Wang, Y.,Hao, M.H.,Grygon, C.A.,Labadia, M.E.,Freeman, D.M.,Davidson, W.,Hopkins, J.L.,Brown, M.L.,Spero, D.M. (deposition date: 2002-09-19, release date: 2003-04-22, Last modification date: 2011-07-13) |
Primary citation | Ward, Y.D.,Thomson, D.S.,Frye, L.L.,Cywin, C.L.,Morwick, T.,Emmanuel, M.J.,Zindell, R.,McNeil, D.,Bekkali, Y.,Giradot, M.,Hrapchak, M.,DeTuri, M.,Crane, K.,White, D.,Pav, S.,Wang, Y.,Hao, M.H.,Grygon, C.A.,Labadia, M.E.,Freeman, D.M.,Davidson, W.,Hopkins, J.L.,Brown, M.L.,Spero, D.M. Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors J.Med.Chem., 45:5471-5482, 2002 Cited by PubMed: 12459015DOI: 10.1021/jm020209i PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report